Potentiated Modulation of Pregnolone on GABA_A Receptors in Behaviorally Stressed Borderline-Hypertensive Rats(Pharmacology)
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概要
- 論文の詳細を見る
The modulatory effects of behavioral stress on [^3H]flunitrazepam, an agonist for the central-type benzodiazepine receptor binding to the GABA_A-benzodiazepine receptor complex, in borderline hypertensive rats (BHR) were examined. In repeatedly immobilized (for 2 weeks, for 2 h/d) BHR, enhancement of [^3H]flunitrazepam binding to the receptor was observed to be potentiated. The percent enhancement of [^3H]flunitrazepam binding in BHR was higher than that in normotensive control Wistar-Kyoto rats. Pregnanolone, a neuroactive steroid that has been reported to be a putative endogenous modulator in the stress response, concentration dependency enhanced [^3H]flunitrazepam binding to the receptor. Enhancement of [^3H]flunitrazepam binding was observed to be potentiated by the same immobilized stress, and the ECSO values of pregnanolone in BHR was significantly lower than those in controls and Email values were higher. From the above results, it can be concluded that neural modulation to behavioral stress, especially in GABAergic neurotransmission, is exaggerated in BHR. We propose strain-specific differences of stress reactivity as an important pathogenetic factor in psychosomatic disorders including stress-induced hypertension. This is supported by reports showing exaggerated cardiovascular and symathoadrenal responses to stress in BHR.
- 社団法人日本薬学会の論文
- 2004-01-01
著者
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LEE Kwang
Department of Sericulture and Entomology, National Institute of Agriculture and Technology
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Choi Hyoung
Aging-associated Vascular Disease Res. Center Coll. Of Medicine Yeungnam Univ.
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Lee Jong-bum
Psychiatry College Of Medicine Yeungnam University
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Lee Jae-tae
Department Of Nuclear Medicine School Of Medicine Kyungpook National University
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HA Jeoung-Hee
Department of Pharmacology. School of Medicine, Kyungpook National University
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Choi Hyoung
Department of Pharmacology, Aging-associated Vascular Disease Research Center, College of Medicine,
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Choi H
Yeungnam Univ. Daegu Kor
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KIM Jong-Yeon
Physiology, College of Medicine, Yeungnam University
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PARK Yong-Hoon
Pediatrics, College of Medicine, Yeungnam University
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KANG Hun-Gu
Psychiatry, College of Medicine, Kyungbook National University
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KANG Byung-Jo
Psychiatry, College of Medicine, Kyungbook National University
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Choi Hyoung
Dep. Of Pharmacology Aging-associated Vascular Disease Res. Center Coll. Of Medicine Yeungnam Univ.
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Lee K
Departments Of Pharmacology College Of Medicine Yeungnam University
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Kang Hun-gu
Psychiatry College Of Medicine Kyungbook National University
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Choi Hyoung
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Kang Byung-jo
Psychiatry College Of Medicine Kyungbook National University
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Kim Jong-yeon
Physiology College Of Medicine Yeungnam University
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Ha Jeoung-hee
Department Of Pharmacology School Of Medicine Kyungpook National University
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Ha Jeoung-hee
Departments Of Pharmacology College Of Medicine Yeungnam University
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Park Yong-hoon
Pediatrics College Of Medicine Yeungnam University
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Lee Kwang
Department Of Bioengineering Yonsei University
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Ha Jeoung-hee
Department Of Pharmacology Kyungpook National University School Of Medicine
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Lee Jae-tae
Department Of Nuclear Medicine Kyungpook National University School Of Medicine
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Lee Kwang
Department of Advanced Technology Fusion (DATF), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea
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