Antioxidant Effects of Aqueous Extract of Terminalia chebula in Vivo and in Vitro(Pharmacology)
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概要
- 論文の詳細を見る
The ripe fruit of Terminalia chebula RETZIUS (T. chebula RETZ) (Combretsceae), which is a native plant in India and Southeast Asia, has traditionally been used as a popular folk medicine for homeostatic, antitussive, laxative, diuretic, and cardiotonic treatments. The objective of this study was to evaluate the protective effects of an aqueous extract of fruit of T. chebula on the tert-butyl hydroperoxide (t-BHP)-induced oxidative injury observed in cultured rat primary hepatocytes and rat liver. Both treatment and pretreatment of the hepatocytes with the T. chebula extract (TCE) significantly reversed the t-BHP-induced cell cytotoxicity and lactate dehydrogenase leakage. In addition, TCE exhibited in vitro ferric-reducing antioxidant activity and 2, 2-diphenyl-1-picry-hydrazyl free radical-scavenging activities. The in vivo study showed that pretreatment with TCE (500 or 1000mg/kg) by gavage for 5 d before a single dose of t-BHP (0.1mmol/kg i.p.) significantly lowered the serum levels of the hepatic enzyme markers aspartate aminotransferase and alanine aminotransferase and reduced the indicators of oxidative stress in the liver, such as the glutathine disulfide content and lipid peroxidation, in a dose-dependent manner. Histopathologic examination of the rat livers showed that TCE reduced the incidence of liver lesions, including hepatocyte swelling and neutrophilic infiltration, and repaired necrosis induced by t-BHP. Based on the results described above, we speculate that TCE has the potential to play a role in the hepatic prevention of oxidative damage in living systems.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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Lee Hyun-sun
Molecular Cancer Res. Center Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Won Nam
Department Of Pathology College Of Medicine Korea University
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JUN Woojin
Department of Food and Nutrition, Chonnam National University
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Jun Woojin
Department Of Food And Nutrition Chonnam National University
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Lee Kwang
Department Of Bioengineering Yonsei University
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Lee Kwangwon
Division Of Food Bioscience & Technology College Of Life Science & Biotechnology Korea Unive
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Lee Kwang
Department Of Food Science College Of Life & Environmental Sciences Korea University
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Kim Kyoung
Department Of Biochemistry Seoul National University College Of Medicine
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Lee Hyun
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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LEE Hojoung
Division of Biotechnology of Genetic Engineering, College of Life & Environmental Sciences, Korea Un
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Kim Kyoung
Department Of Food Science College Of Life & Environmental Sciences Korea University
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Lee Hyun-Sun
Department of Food Science, College of Life & Environmental Sciences, Korea University
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Lee Kwang
Department of Advanced Technology Fusion (DATF), Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea
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