O-Palmitoylcurdlan Sulfate (OPCurS)-Coated Liposomes for Oral Drug Delivery(MEDICAL BIOTECHNOLOGY)
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概要
- 論文の詳細を見る
O-Palmitoylcurdlan sulfate (OPCurS) was applied to the liposomal surface to improve the stability of liposomes. To synthesize OPCurS, curdlan was chemically sulfated and then modified with a palmitoyl derivative. The synthesized OPCurS was characterized by Fourier transform-infrared spectroscopy (FT-IR). OPCurS-coated liposomes prepared by the solvent evaporation method were characterized for size, shape, surface charge, and stability in simulated gastric fluid (SGF) and sodium cholate solution. The sizes of OPCurS-coated liposomes increased with the OPCurS content of liposomes and ζ potential decreased when OPCurS was applied to the liposomal surface. With the increase in the content of OPCurS attached to the liposomal surface, the stability of liposomes in SGF and sodium cholate solution was gradually induced and the stability was most improved at a lipid/OPCurS weight ratio of 1.5. Liposomes not coated with OPCurS released 99.5±2.3% of the initial 5-carboxyfluorescein (5-CF) content, whereas OPCurS-coated liposomes released 53.7±3.7%. OPCurS on the surface of liposomes suppressed the release of 5-CF. Theses results indicate that OPCurS-coated liposomes can be effectively used as a drug delivery carrier via oral administration.
- 社団法人日本生物工学会の論文
- 2005-09-25
著者
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LEE Hyun
Department of Occupational Medicine, College of Medicine, Dong-A University
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Lee Hyun
Department Of Microbiology Chonnam National University Medical School
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Lee Chang
Interdisciplinary Program of Biomedical Engineering, Chonnam National University
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Lee Ki
Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National U
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Lee Ki
Faculty Of Applied Chemical Engineering And The Research Institute For Catalysis Chonnam National Un
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Lee Hyun
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Lee Chang
Interdisciplinary Program Of Biomedical Engineering Chonnam National University
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Lee Hyun-Chul
Department of Microbiology, Chonnam National University Medical School
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Lee Ki-Young
Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National University
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Lee Chang-Moon
Interdisciplinary Program of Biomedical Engineering, Chonnam National University
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