Neuroprotective Effect of Buddleja officinalis Extract on Transient Middle Cerebral Artery Occlusion in Rats(Pharmacology)
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概要
- 論文の詳細を見る
The flower buds of Buddleja officinalis MAXIM (Loganiaceae) are used to treat headache and inflammatory diseases in traditional Korean medicine. In the present study, the neuroprotective effects of the methanolic extract of B. officinalis (BOME) and of its hexane fraction (BOHF) were investigated in a middle cerebral artery occlusion (MCAo, 120min occlusion, 24 h reperfusion) Sprague-Dawley rat model. BOME or BOHF (100mg/kg, p.o.) was twice administered 30min before the onset of MCAo and 2h after reperfusion. BOME and BOHF treated groups showed infarct volumes reduced by 33.9% and 68.2%, respectively, at 2 h occlusion. In BOHF treated animals, cyclooxygenase-2 and iNOS inductions were inhibited in ischemic hemispheres at both the mRNA and protein levels. Furthermore, in vitro studies showed that BOME and BOHF both inhibited LPS-induced nitric oxide production in BV-2 mouse microglial cells. These results suggest that the anti-inflammatory and the microglial activation inhibitory effects of B. officinalis extract may contribute to its neuroprotective effects in brain ischemia.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
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Kim Yoon
Department of Obstetrics and Gynecology, Microbiology and Immunology, Chonnam National University Me
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Kim Yoon
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Choi Hyoung
Department of Pharmacology, Aging-associated Vascular Disease Research Center, College of Medicine,
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KIM Hocheol
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University
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Kim Mi-yeon
Korea Institute Of Science And Technology For Eastern Medicine (kistem) Neumed Co. Ltd.
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PARK Yoo
Department of Internal Medicine College of Medicine, Chosun University
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Park Yoo
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Choi Hyoung
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Kim Hocheol
韓国
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Kim Yoon
Department Of Anesthesiology And Pain Medicine Chungnam National University Hospital
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LEE Dae-Hee
Department of Agricultural Biotechnology and The BioMAX Institute, Seoul National University
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Lee Dae-hee
Department Of Herbal Pharmacology College Of Oriental Medicine Kyung Hee University
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HA Nina
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee Universit
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BU Yung-Min
Department of Herbal Pharmacology, College of Pharmacy, Woosuk University
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Kim Hocheol
Department Of Herbal Pharmacology College Of Oriental Medicine Kyung Hee University:korea Institute
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Ha Nina
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Bu Yung-min
Department Of Herbal Pharmacology College Of Pharmacy Woosuk University
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