Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
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概要
- 論文の詳細を見る
Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-<sc>D</sc>-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.
- 社団法人 日本薬理学会の論文
- 2003-05-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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Kim Chang-ju
韓国
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Lee Jong-soo
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Sun
Graduate School Of East-west Medicine Kyung Hee Univ.
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Lee J‐s
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Sung-soo
Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University
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Kim H
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee Jong-sung
Biotoxtech Co. Ltd.
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Lee Jong-sung
韓国
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Kim S
Graduate School Of East-west Medicine Kyung Hee Univ.
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LEE Pyeongjae
Department of Natural Medicine Resources, Semyung University
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Y
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐s
Seoul National Univ. Seoul Kor
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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KIM Yong-Sik
Department of Orthopedic Surgery, St. Mary's Hospital, Catholic University of Korea
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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KIM Hocheol
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University
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Kim Dae-keun
Department Of Herbal Pharmacology College Of Pharmacy Woosuk University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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LEE Jongseok
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee Universit
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SON Dongwook
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee Universit
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KIM Sun-Yeou
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee Universit
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Kim Y‐j
Chung‐ang Univ. Seoul Kor
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Kim Hong
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee J
Kyung Hee Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Lee Jongseok
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Yong-sik
Department Of Orthopedic Surgery St. Mary's Hospital Catholic University Of Korea
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Son Dongwook
Department Of Herbal Pharmacology Graduate School Of East-west Medical Science Kyung Hee University
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Lee Pyeongjae
Department Of Natural Medicine Resources Semyung University
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Lee Pyeongjae
Department Of Sericulture And Entomology National Institute Of Agricultural Science & Technology
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Lee J
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Kim H
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Hocheol
Department Of Herbal Pharmacology College Of Oriental Medicine Kyung Hee University:korea Institute
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Son Dongwook
Kt&g Central Res. Inst.
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Lee Pyeongjae
Department of Agricultural Biology, National Institute of Agricultural Science & Technology
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Kim Yong-Sik
Department of Microbiology, College of Medicine, Soonchunhyang University
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Lee Jongseok
Department of Chemical and Biomolecular Engineering, Sogang University
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