Protective Effects of Puerariae flos Against Ethanol-Induced Apoptosis on Human Neuroblastoma Cell Line SK-N-MC
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概要
- 論文の詳細を見る
Puerariae flos (PF) is an oriental medical herb for alcohol abuse. To investigate whether PF possesses protective effects against ethanol (EtOH)-induced cytotoxicity in the central nervous system, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometric analysis, DNA fragmentation assay, and reverse transcription-polymerase chain reaction were performed on SK-N-MC human neuroblastoma cells. Cells treated with EtOH exhibited several apoptotic features, while those pre-treated with PF prior to EtOH exposure showed a decreased occurrence of apoptotic features. In addition, PF pre-treatment inhibited the EtOH-induced increase in caspase-3 mRNA expression. These results suggest that PF may exert protective effects against EtOH-induced apoptosis in human neuroblastoma cells.
- 社団法人 日本薬理学会の論文
- 2001-12-01
著者
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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KIM Yeunhee
Department of Biochemistry, College of Oriental Medicine, Semyung University
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CHUNG Joo-Ho
Departments of Pharmacology, College of Medicine, Kyung Hee University
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YIM Sung-Vin
Department of Pharmacology, College of Medicine, Kangwon National University
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Chung J‐h
Departments Of Pharmacology College Of Medicine Kyung Hee University
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Yim Sung-vin
韓国
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KIM Youn-Jung
Departments of Physiology Kyung Hee University
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CHUNG Joo-Ho
Pharmacology, College of Medicine, Kyung Hee University
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐s
Seoul National Univ. Seoul Kor
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Chung Joo-ho
Departments Of Pharmacology College Of Medicine Kyung Hee University
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐j
Chung‐ang Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Yim Sung-vin
Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi
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Kim Youn-jung
Department Of Applied Chemistry Kyung Hee University
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