Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells (Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Ginseng radix, the root of Panax ginseng C. A. MEYER (Araliaceae), is one of the best-known Oriental medicinal herbs with numerous therapeutic applications. To investigate whether Ginseng radix possesses a protective effect against 1-methyl-4-phenylpyridine (MPP^+)-induced cytotoxicity in neuronal cells, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, DNA fragmentation assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and caspase-3 enzyme assay were performed on PC 12 neuronal cells. Cells treated with MPP^+ exhibited various apoptotic features, while cell pretreated with Ginseng radix prior to MPP^+ exposure showed a decrease in the occurrence of apoptotic features. These results suggest that Ginseng radix may exert a protective effect against MPP^+-induced apoptosis in PC12 cells.
- 社団法人日本薬学会の論文
- 2003-12-01
著者
-
Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim C‐j
Kyung Hee Univ. Seoul Kor
-
KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
-
JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
-
SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
-
KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
-
KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
-
SHIN Mal-Soon
Department of Physiology, College of Medicine, Kyung Hee University
-
Kim Chang-ju
韓国
-
Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Ee-hwa
韓国
-
Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
-
Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
-
Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
関連論文
- Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring
- Maternal Alcohol Administration Suppresses Expression of Nitric Oxide Synthase in the Hippocampus of Offspring Rats
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Atractylodes japonica Suppresses Lipopolysaccharide-Stimulated Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Macrophages (Pharmacology)
- Protective Effect of Aqueous Extract of Ginseng radix against 1-Methyl-4-phenylpyridinium-Induced Apoptosis in PC12 Cells (Pharmacology)
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Folium mori Increases Cell Proliferation and Neuropeptide Y Expression in Dentate Gyrus of Streptozotocin-Induced Diabetic Rats
- Bee Venom Induces Apoptosis and Inhibits Expression of Cyclooxygenase-2 mRNA in Human Lung Cancer Cell Line NCI-H1299
- Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats
- Effect of Puerariae radix on c-Fos Expression in Hippocampus of Alcohol-Intoxicated Juvenile Rats(Pharmacology)
- A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats
- Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats
- Serotonin Induces Apoptosis in PGT-β Pineal Gland Tumor Cells
- Effects of Corydalis Tuber on synthesis of NO and PGE_2 in murine macrophage RAW 264.7 cells stimulated by LPS(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Scie
- Nitric Oxide Induces Apoptosis in Mouse C2C12 Myoblast Cells
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Protective Effects of Puerariae flos Against Ethanol-Induced Apoptosis on Human Neuroblastoma Cell Line SK-N-MC
- Harpagophytum procumbens Suppresses Lipopolysaccharide-Stimulated Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Fibroblast Cell Line L929
- Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons
- Effect of postnatal treadmill exercise on c-Fos expression in the hippocampus of rat pups born from the alcohol-intoxicated mothers
- Maternal swimming during pregnancy enhances short-term memory and neurogenesis in the hippocampus of rat pups
- Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats
- Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia
- Effects of Oleamide on Choline Acetyltransferase and Cognitive Activities(Food & Nutrition Science)
- Protective Effect of Methanol Extract of Uncaria rhynchophylla Against Excitotoxicity Induced by N-Methyl-D-Aspartate in Rat Hippocampus
- Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
- Amygdalin Induces Apoptosis through Regulation of Bax and Bcl-2 Expressions in Human DU145 and LNCaP Prostate Cancer Cells(Pharmacology)
- Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons(Pharmacology)
- Antinociceptive Effect of Amygdalin Isolated from Prunus armeniaca on Formalin-Induced Pain in Rats(Pharmacognosy)
- Armeniacae semen Extract Suppresses Lipopolysaccharide-Induced Expressions of Cycloosygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells(Pharmacology)
- Effect of Ginseng radix on c-Fos Expression in the Hippocampus of Streptozotocin-Induced Diabetic Rats
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Ginseng radix Increases Cell Proliferation in Dentate Gyrus of Rats with Streptozotocin-Induced Diabetes
- Related Factors with Sa-Sang Constitution(International Conference on Mind Body Science : Physical and Physiological Approach joint with The Eighteenth Symposium on Life Information Science)
- Protective Effects of Kaempferol (3,4′,5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Activation Effects of Allium Tuberosum Rottl. on Choline Acetyltransferase
- Protective Effects of Kaempferol (3,4',5,7-tetrahydroxyflavone) against Amyloid Beta Peptide (Aβ)-Induced Neurotoxicity in ICR Mice
- Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats
- Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment
- Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups