Effect of Ginseng radix on c-Fos Expression in the Hippocampus of Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.
- 社団法人 日本薬理学会の論文
- 2003-02-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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CHANG Hyun-Kyung
Department of Physiology, College of Medicine, Kyung Hee University
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LEE Taeck-Hyun
Department of Physiology, College of Medicine, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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KIM Young-Pyo
Department of Sports and Leisure Studies, Hannam University
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Kim Chang-ju
韓国
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Lee T‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Lee Taeck-hyun
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐s
Seoul National Univ. Seoul Kor
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Chang H‐k
Department Of Physiology College Of Medicine Kyung Hee University
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐j
Chung‐ang Univ. Seoul Kor
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Lee Taeck-hyun
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Young-pyo
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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