Effects of Oleamide on Choline Acetyltransferase and Cognitive Activities(Food & Nutrition Science)
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概要
- 論文の詳細を見る
We screened 50 Korean traditional natural plants to measure the activation effect on choline acetyltransferase and attenuation of scopolamine-induced amnesia. The methanolic extracts from Zizyphus jujuba among the tested 50 plants, showed the highest activatory effect (34.1%) on choline acetyltransferase in vitro. By sequential fractionation of Zizyphus jujuba, the active component was finally identified as cis-9-octadecenoamide (oleamide). After isolation, oleamide showed a 65% activation effect. Administration of oleamide (0.32%) to mice significantly reversed the scopolamine-induced memory and/or cognitive impairment in the passive avoidance test and Y-maze test. Injection of scopolamine to mice impaired performance on the passive avoidance test (31% decrease in step-through latency), and on the Y-maze test (16% decrease in alternation behavior). In contrast, mice treated with oleamide before scopolamine injection were protected from these changes (12-25% decrease in step-through latency ; 1-10% decrease in alternation behavior). These results suggest that oleamide should be a useful chemopreventive agent against Alzheimer's disease.
- 社団法人日本農芸化学会の論文
- 2003-06-23
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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Kim Byung-Gee
School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, Institut
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Kim Chang-ju
韓国
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Kim Hye-kyung
Dep. Of Food And Biotechnology Hanseo Univ.
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Kim Hye
韓国
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Heo Ho-jin
Jeonnam Innovation Agency
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Choi Soo
Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Kim Byung-gee
School Of Chemical Engineering And Institute For Molecular Biology And Genetics Seoul National Unive
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Kim Byung-gee
School Of Chemical & Biological Engineering Seoul National University
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Shin Dong-hoon
韓国
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Shin D‐h
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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Shin Dong-hoon
Graduate School Of Biotechnology Korea University
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Shin Dong‐hoon
Department Of Food And Biotechnology Korea University
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Shin Dong-hoon
Millimeter-wave Innovation Technology Research Center (mint) Dongguk University
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Kim Mi-Jeong
Brain Korea 21 Project for Medicine, Yonsei University
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SUH Young-Min
Graduate School of Biotechnology, Korea University
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KIM Mi-Jeong
Graduate School of Biotechnology, Korea University
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CHOI Soo-Jung
Graduate School of Biotechnology, Korea University
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KIM Hye-Kyung
Department of Food Biotechnology, Hanseo University
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KIM Eunki
Department of Biological Engineering, Inha University
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CHO Hong-Yon
Graduate School of Biotechnology, Korea University
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HEO Ho-Jin
Graduate School of Biotechnology, Korea University Seoul
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PARK Young-June
Graduate School of Biotechnology, Korea University Seoul
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CHANG Yun-Jeong
Graduate School of Biotechnology, Korea University Seoul
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HONG Bumshik
Graduate School of Biotechnology, Korea University Seoul
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Kim Mi
Department Of Food And Biotechnology Korea University
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Cho Hong
Dep. Of Food And Biotechnology Korea Univ.
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Cho Hong-yon
Dep. Of Food Technol. Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Eun-ki
Dep. Of Biological Engineering Inha Univ.
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Cho Hong
Graduate School Of Biotechnology Korea University
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Cho Hong-yon
Department Of Food Sience And Biotechnology Graduate School Of Biotechnology Korea University
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Suh Young-min
Graduate School Of Biotechnology Korea University
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Hong B‐s
Department Of Food Science And Technology Graduate School Of Biotechnology Korea University
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Kim Hyun-mi
Department Of Pharmaceutical Lab. Central Research Institute Ilyang Pharm Co.
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Shin D‐h
Dep. Of Food And Biotechnology Korea Univ.
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Park Y‐j
Graduate School Of Biotechnology Korea University Seoul
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Kim Eunki
Department Of Biological Engineering Inha University
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Hong Bumshik
Department Of Food And Biotechnology Korea University
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Chang Yun-jeong
Graduate School Of Biotechnology Korea University Seoul
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Kim Hye
Department of Food and Biotechnology, Hanseo University
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Kim Mi-Jeong
Department of Food and Biotechnology, Korea University
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SHIN Dong
Department of Food and Biotechnology, Korea University
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KIM Hye-Kyung
Department of Food and Biotechnology, Hanseo University
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