Harpagophytum procumbens Suppresses Lipopolysaccharide-Stimulated Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Fibroblast Cell Line L929
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概要
- 論文の詳細を見る
Harpagophytum procumbens (Pedaliaceae) has been used for the treatment of pain and arthritis. The effect of Harpagophytum procumbens against lipopolysaccharide-induced inflammation was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E2 (PGE2) immunoassay, and nitric oxide detection on mouse fibroblast cell line L929. The aqueous extract of Harpagophytum procumbens was shown to suppress PGE2 synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells. These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and iNOS expressions.
- 社団法人 日本薬理学会の論文
- 2003-11-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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LIM Sabina
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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HAN Seung-Moo
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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PARK Hi-Joon
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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SHIN Insop
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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LEE Ji-Suk
Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute
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Kim Chang-ju
韓国
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Lee Jong-soo
Department Of Physiology College Of Medicine Kyung Hee University
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Shin H‐d
College Of Nursing Science Kyung Hee University
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Park H‐j
Korea Univ. Seoul Kor
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Lee Jong-sung
Biotoxtech Co. Ltd.
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Lee Jong-sung
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Nam-jae
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Kim Jin-woo
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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KIM Kyung-Ah
Research Group of Pain and Neuroscience in Vision 2000 Project, East-west Medical Research Institute
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Kim Kyung-ah
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Han Seung-moo
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Shin Insop
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Lim Sabina
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee J
Kyung Hee Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Park Hi-joon
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee Ji-suk
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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Lee J
Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute
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