Antinociceptive Effect of Amygdalin Isolated from Prunus armeniaca on Formalin-Induced Pain in Rats(Pharmacognosy)
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概要
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Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums. To investigate the pain-relieving activity of amygdalin, we induced pain in rats through intraplantar injection of formalin, and evaluated the antinociceptive effect of amygdalin at doses of 0.1, 0.5, 1.0, and 10.0 mg/kg-body weight by observing nociceptive behavior such as licking, biting and shaking, the number of Fos-immunoreactive neurons in the spinal cord, and the mRNA expression of inflammatory cytokines in the plantar skin. The intramuscular injection of amygdalin significantly reduced the formalin-induced tonic pain in both early (the initial 10 min after formalin injection) and late phases (10-30 min following the initial formalin injection). During the late phase, amygdalin did reduce the formalin-induced pain in a dose-dependent manner in a dose range less than 1 mg/kg. Molecular analysis targeting c-Fos and inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) also showed a significant effect of amygdalin, which matched the results of the behavioral pain analysis. These results suggest that amygdalin is effective at alleviating inflammatory pain and that it can be used as an analgesic with anti-nociceptive and anti-inflammatory activities.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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LEE Hye-Jung
Acupuncture & Meridian Science Research Center, Institute of Oriental Medicine, Kyunghee University
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HAHM Dae-Hyun
Acupuncture & Meridian Science Research Center, Institute of Oriental Medicine, Kyunghee University
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Lee Han-chang
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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Lee Hye-jung
Acupuncture & Meridian Science Research Center Kyung-hee University:institute Of Oriental Medici
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Hahm Dae-hyun
Acupuncture And Meridian Science Research Center Kyung Hee University
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Hahm Dae-hyun
Acupuncture & Meridian Science Research Center Kyung-hee University:institute Of Oriental Medici
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Lee H‐j
Department Of Meridian And Acupuncture College Of Oriental Medicine Kyung Hee University
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Yun Young-ju
Department Of Life Science Sookmyung Women's University
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Shim Insop
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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YANG Young
Department of Obstetrics and Gynecology, Yonsei University College of Medicine
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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HWANG Hye-Jeong
Acupuncture & Meridian Science Research Center, Kyung Hee University
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KIM Pil
Division of Biotechnology, The Catholic University of Korea
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YIN Chang
Acupuncture & Meridian Science Research Center, Kyung Hee University
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Hahm Dae-hyun
Institute Of Oriental Medicine College Of Korean Medicine Kyung Hee University
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Kim Pil
Division Of Biotechnology The Catholic University Of Korea
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Hwang Hye-jeong
Acupuncture & Meridian Science Research Center Kyung Hee University
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Yang Young
Department Of Obstetrics And Gynecology And Division Of Prenatal Genetic Clinics And The Institute O
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Lee H.-j.
Acupuncture And Meridian Science Research Center (amsrc) Kyung Hee University
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KIM Pil
Division of Applied Life Science, Gyeongsang National University:Institute of Agriculture and Life Science, Gyeongsang National University
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