Antidepressant Effects of Soyo-san on Immobilization Stress in Ovariectomized Female Rats(Pharmacology)
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概要
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Soyo-san is a traditional oriental medicinal formula, a mixture of 9 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Soyo-san on repeated stress-induced alterations of learning and memory on a Morris water maze (MWM) task and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyl-transferase (ChAT) and reactivity of acetylcholinesterase (AChE) in the hippocampus, and the serum levels of corticosterone were assessed after behavioral testing. The female rats were randomly divided into three groups: the nonoperated and nonstressed group (normal), the ovariectomized and stressed group (control), and the ovariectomized, stressed and Soyo-san treated group (SOY). The rats were exposed to immobilization stress (IMO) for 14 d (2 h/d), and Soyo-san (400 mg/kg, i.p.) was administered 30 min before IMO stress. Treatments with SOY caused significant reversals of the stress-induced deficits in learning and memory on a spatial memory task, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT and AChE reactivities (p<0.05, respectively). The serum level of corticosterone in the SOY group was significantly lower than that in the control group (p<0.05). These results suggest that Soyo-san might prove to be an effective antidepressant agent.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Oh Jin
Department Of Urology Seoul National University College Of Medicine
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PYUN Kwang-Ho
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Lim Eun-mee
Department Of Oriental Gynecology Oriental Hospital College Of Oriental Medicine Kyung-won Universit
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Pyun Kwang-ho
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Oh Jin
Department Of Mechanical Engineering Pohang University Of Science And Technology
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Oh Jin
Department Of Oriental Medical Science Graduate School Of East-west Medical Science Kyung Hee Univer
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KIM Yoon-Sang
Department of Oriental Gynecology, Oriental Hospital, College of Oriental Medicine, Kyung-won Univer
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PARK Hyun-Jung
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Kim Yoon-sang
Department Of Oriental Gynecology Oriental Hospital College Of Oriental Medicine Kyung-won Universit
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Park Hyun-jung
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Oh Jin
Department Of Internal Medicine Dongguk University Ilsan Hospital
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Oh Jin
Department of Advanced Materials Engineering, Yonsei University, Seoul 120-749, Korea
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