Effects of Methanol Extract of Uncariae Ramulus et Uncus on Ibotenic Acid-Induced Amnesia in the Rat
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概要
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In the present study, we investigated the effects of Uncariae Ramulus et Uncus (UR) on learning and memory in the Morris water maze task and the central cholinergic system of rats with excitotoxic medial septum (MS) lesion. In the water maze test, the animals were trained to find a platform in a fixed position during 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. Ibotenic lesion of the MS showed impaired performance of the maze test and severe cell losses in the septohippocampal cholinergic system (SHC), as indicated by decreased choline acetyltransferase-immunoreactivity and acetylcholinesterase-reactivity in the hippocampus. Daily administrations of UR (100 mg/kg, i.p.) for 21 consecutive days produced significant reversals of ibotenic acid-induced deficit in learning and memory. These treatments also reduced the loss of cholinergic immunoreactivity in the hippocampus induced by ibotenic acid. These results demonstrated that impairments of spatial learning and memory may be attributable to degeneration of SHC neurons and that UR ameliorated learning and memory deficits partly through neuroprotective effects on the central acetylcholine system. Our studies suggest that UR may be useful in the treatment of Alzheimer’s disease.
- 2004-11-20
著者
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Kim Ji
韓国
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KIM Ji
Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University
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CHUNG Jin
Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University
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LEE Young
Cell and Gene Therapy Research Institute and Department of Anatomy, Pochon Cha University
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PARK Sepill
Maria Biotech and Maria Infertility Hospital Medical Institute
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KIM Jang
Department of Pediatrics, Division of Korean Oriental Medicine, Dongguk University
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HAHM Dae
Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University
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LEE Hye
Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University
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SHIM Insop
Graduate School of East-West Medical Science, College of Oriental Medicine, Kyung Hee University
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Lee Hye
韓国
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Lee Hye
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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Hahm D
Korea Advanced Inst. Science And Technology Taejon Kor
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Hahm Dae
韓国
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Shim Insop
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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Kim Ji
Department Of Integrative Medicine Immunology And Cell Biology Core Lab College Of Medicine The Cath
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Lee Young
Cell And Gene Therapy Research Institute And Department Of Anatomy Pochon Cha University
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Kim Jang
Department Of Medical Humanities And Social Sciences University Of Ulsan College Of Medicine
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Chung Jin
Graduate School Of East-west Medical Science College Of Oriental Medicine Kyung Hee University
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Kim Ji
Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyunghee University
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Kim Jang
Department of Electrical and Electronic Engineering, Yonsei University, Seoul 120-749, Korea
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