Effect of Crude Saponin of Korean Red Ginseng on High-Fat Diet-Induced Obesity in the Rat
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概要
- 論文の詳細を見る
The anti-obesity effects of crude saponin (CS) of Korean red ginseng (KRG) were investigated in the rat fed a high-fat (HF) diet. Male Sprague-Dawley (SD) rats became obese by feeding the HF diet over 5 weeks, while the control rats were fed a normal diet, and then both groups were treated with CS (200 mg/kg, i.p.) for 3 weeks. The body weight, food consumption, adipose tissues, and expression of appetite peptides such as leptin and neuropeptide Y (NPY) were investigated in rats fed normal and HF diet after treatment of CS. Administration of CS reduced body weight, food intake, and fat content in HF diet rats in a manner similar to those of the normal diet fed rats. The hypothalamic NPY expression and serum leptin level were reduced in HF diet rats after CS treatment. Our results suggest that CS may be useful in the treatment of obesity and related disorders as anti-obesity agents.
- 社団法人 日本薬理学会の論文
- 2005-01-20
著者
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KIM Ji
Department of Polymer Science and Engineering, Kumoh National Institute of Technology
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Kim Ji
韓国
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KIM Jang
Department of Pediatrics, Division of Korean Oriental Medicine, Dongguk University
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LEE Hye
Departments of Pathology, Seoul National University College of Medicine
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Lee Hye
韓国
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Lee Hye
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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Hahm D
Korea Advanced Inst. Science And Technology Taejon Kor
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Hahm Dae
韓国
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Hahm Dae
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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Hahm Dae
Department Of Biotechnology Korea Advanced Institute Of Science And Technology
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Lee Hye
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyung-hee University
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SHIM Insop
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea
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Shim Insop
Department Of Integrative Medicine College Of Medicine The Catholic University Of Korea
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Shim Insop
Department Of Oriental Medical Science Graduate School Of East-west Medical Science
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Kim Ji
Department Of Integrative Medicine Immunology And Cell Biology Core Lab College Of Medicine The Cath
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Kim Ji
Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center
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YANG Deck
Oriental Medical Material and Processing, Kyung Hee University
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Yang Deck
Oriental Medical Material And Processing Kyung Hee University
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Kim Jang
Department Of Medical Humanities And Social Sciences University Of Ulsan College Of Medicine
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Kim Ji
Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea
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Kim Jang
Department of Electrical and Electronic Engineering, Yonsei University, Seoul 120-749, Korea
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