Anti-obesity Effect of Dioscorea nipponica Makino with Lipase-inhibitory Activity in Rodents(Food & Nutrition Science)

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概要

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• In the process of screening for pancreatic lipase inhibitors, which could be used as an anti-obesity measure, the methanol extract of Dioscorea nipponica Makino powder (DP) appeared to have potent inhibitory activity against porcine pancreatic lipase with an IC_<50> value of 5-10 μg/ml, where the enzyme activity was assayed by using 4-methylumbelliferyl oleate as a substrate. Further purification of active components present in the herb generated dioscin that belongs to the saponin family. Dioscin and its aglycone, diosgenin, both suppressed the time-dependent increase of blood triacylglycerol level when orally injected with corn oil to mice, suggesting their inhibitory potential against fat absorption. Sprague-Dawley rats fed on a high-fat diet containing 5% Dioscorea nipponica Makino and 40% beef tallow gained significantly less body weight and adipose tissue than control animals fed on a high-fat diet alone during an 8-week experimental period (P<0.05).

• 社団法人日本農芸化学会の論文
• 2003-07-23

著者

• LIM Jin

  Department of Dental Biomaterials Science and Dental Research Institute, School of Dentistry, Seoul

• KIM Ji

  Department of Polymer Science and Engineering, Kumoh National Institute of Technology

• Lee Jeong

  Department of Obstetrics and Gynaecology, College od Medicine, Soonchunhyang University

• Kim Sung

  Department of Bioengineering and Technology, College of Engineering, Kangwon National University

• Lim Jin

  Dep. Of Animal Sci. And Biotechnology Kyungpook National Univ.

• SON Kun

  Department of Food Nutrition, Andong National University

• Son K

  Department Food & Nutriton Andong National University

• Son Kun

  Dep. Of Food Sci. And Nutrition Andong National Univ.

• Kim Ji

  Dep. Of Food Sci. And Nutrition Andong National Univ.

• Kim Ji

  Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center

• Kim Sung

  Department Of Anatomy

• KWON Chong-Suk

  Department of Food Science and Nutrition, Andong National University

• SOHN Ho

  Department of Food Science and Nutrition, Andong National University

• KIM Jong-Sang

  Department of Animal Science and Biotechnology, Kyungpook National University

• Son Kun

  Department Food & Nutriton Andong National University

• Kwon Chong-suk

  Dep. Of Food Sci. And Nutrition Andong National Univ.

• Sohn Ho

  Dep. Of Food Sci. And Nutrition Andong National Univ.

• Kim J

  Department Of Biological Sciences Korea Advanced Institute Of Science And Technology

• Kim Sung

  Department Of Animal Science And Biotechnology Kyungpook National University

• Lee Jeong

  Department Of Clothing And Textiles Gyeongsang National University

• Kim Jonghwa

  Department Of Food Science And Engineering Woo Suk University

• Kwon Chong-suk

  Department Of Food Science And Nutrition Andong National University

• Kim Jong-sang

  Department Of Animal Science And Biotechnology Kyungpook National University

• Sohn Ho

  Department Of Food Science And Nutrition Andong National University

• Lim Jin

  Department Of Animal Science And Biotechnology Kyungpook National University

• Lee Jeong

  Department Of Animal Science And Biotechnology Kyungpook National University

• Lee Jeong

  Department Of Anesthesiology And Pain Medicine Yonsei University College Of Medicine

• Kim Ji

  Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea

• Kim Sung

  Department of Advanced Materials Engineering for Information and Electronics, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea

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