Re-evaluation of the Antioxidant Prenylated Flavonoids from the Roots of Sophora flavescens(Pharmacognosy)
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概要
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The objective of this research was to re-evaluate the antioxidant effects of the prenylated flavonoids from Sophora flavescens via in vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), peroxynitrite (ONOO^-), and total reactive oxygen species (ROS) assays. In addition, a further examination of kuraridinol, kurarinol, and kurarinone, also isolated from S. flavescens, was carried out by the inhibition of terf-butylhydroperoxide (t-BHP)-induced intracellular ROS generation and f-BHP-induced activation of nuclear factor-kappaB (NF-κB). Upon re-examination of the ethyl acetate (EtOAc) soluble fraction of S. flavescens, two major prenylated chalcones, including kuraridin and kuraridinol, along with a minor prenylated flavonol, kushenol C, were isolated as good DPPH scavengers. This was in contrast to the prenylated flavanones, sophoraflavanone G and kurarinone, which were isolated from the methylene chloride (CH_2Cl_2) fraction of the same source. Five flavanones consisting of kushenol E, leachianone G, kurarinol, sophoraflavanone G, and kurarinone exhibited significant antioxidant potentials in the ABTS, ONOO^-, and total ROS assays; however, the prenylated chalcones and prenylated flavonol showed more potent scavenging/inhibitory activities than the prenylated flavanones. Therefore, the prenylated chalcones and prenylated flavonol, rather than the prenylated flavanones, may make important contributions toward the marked antioxidant capacities of S. flavescens. Furthermore, kuraridinol, kurarinol, and kurarinone showed significant inhibitory activities against intracellular ROS levels as well as NF-κB activation by t-BHP. Overall, the results indicate that S. flavescens and its prenylated flavonoids may possess good anti-inflammatory activity, which is implicated in their significant antioxidant activity.
- 社団法人日本薬学会の論文
- 2008-05-01
著者
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KIM Ji
Department of Polymer Science and Engineering, Kumoh National Institute of Technology
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JUNG Hyun
Division of Applied Plant Sciences, Sangji University
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Yoon Na
Division Of Food Science And Biotechnology Pukyong National University
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Lim Hyun
Department Of Aquaculture West Sea Fisheries Research Institute National Fisheries Research And Deve
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Kim Ji
Department Of Anesthesiology And Pain Medicine Gachon Medical School Gil Medical Center
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Kim Ji
Department Of Pharmacy Pusan National University
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Choi Jae
Division of Food Science and Biotechnology, Pukyong National University
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Jeong Da-mi
Division Of Food Science And Biotechnology Pukyong National University
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CHUNG Hae
Department of Pharmacy, Pusan National University
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Jung Hyun
Division Of Food Science And Biotechnology Pukyong National University
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Lim Hyun
Department Of Pharmacy Pusan National University
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Chung Hae
Department Of Pharmacy Pusan National University
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Chung Hae
Department Of Pharmacy College Of Pharmacy:longevity Life Science And Technology Institutes Pusan Na
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Choi Jae
Division Of Food Science And Biotechnology Pukyong National University
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Lim Hyun
Department Of Anesthesiology Yonsei University Wonju College Of Medicine
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Chung Hae
Department Of Pediatrics Chonnam National University Medical School
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Chung Hae
Department Of Kinesiology And Community Health University Of Illinois
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Kim Ji
Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea
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Choi Jae
Division of Cardiology, Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea
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