Anticholinesterase and Antioxidant Constituents from Gloiopeltis furcata
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概要
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Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(3-hydroxy-5-oxotetrahydrofuran-3-yl)acetic acid (1), glutaric acid (2), succinic acid (3), nicotinic acid (4), (E)-4-hydroxyhex-2-enoic acid (5), cholesterol (6), 7-hydroxycholesterol (7), uridine (8), glycerol (9), 5-(hydroxymethyl)-2-methoxybenzene-1,3-diol (10), (5E,7E)-9-oxodeca-5,7-dienoic acid (11), (Z)-3-ethylidene-4-methylpyrrolidine-2,5-dione (12), dehydrovomifoliol (13), loliolide (14), cholesteryl stearate (15), palmitic acid (16), cis-5,8,11,14,17-eicosapentaenoic acid (17) and α-linolenic acid (18) on the basis of spectroscopic and chemical evidences. Their anticholinesterase and antioxidant activities were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO−). All isolated compounds (1—18) exhibited moderate AChE inhibitory activities with IC50 values ranging from 1.14—12.50 μg/ml, whereas 1, 7, 9, 17, and 18 showed mild BChE inhibitory activities with IC50 values ranging from 5.57—15.89 μg/ml. Although most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO−, 5 and 10 showed good DPPH radical scavenging activity, and 5, 10, and 16 showed potent ONOO− scavenging activity.
- 公益社団法人 日本薬学会の論文
著者
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JUNG Hyun
Division of Applied Plant Sciences, Sangji University
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Woo Mi
College Of Pharmacy Catholic University Of Daegu
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Min Byung
College of Pharmacy, Catholic University of Daegu
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Choi Jae
Division of Food Science and Biotechnology, Pukyong National University
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FANG Zhe
College of Pharmacy, Catholic University of Daegu
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Jeong Su
College of Pharmacy, Catholic University of Daegu
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Choi Jae
Division Of Food Science And Biotechnology Pukyong National University
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JUNG Hyun
Division of Food Science and Biotechnology, Pukyong National University
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Choi Jae
Division of Cardiology, Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea
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