Capsofulvesins A–C, Cholinesterase Inhibitors from Capsosiphon fulvescens
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概要
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Activity-directed isolation of the n-hexane and dichloromethane fractions of Capsosiphon fulvescens resulted in the identification of four new glycolipids (1–3): (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-O-(4Z,7Z,10Z,13Z-hexadecatetraenoyl)-3-O-β-D-galactopyranosyl glycerol (1, capsofulvesin A), (2S)-l-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(10Z,13Z-hexadecadienoyl)-3-O-β-D-galactopyranosyl glycerol (2, capsofulvesin B), (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galacatopyranosyl glycerol (3, capsofulvesin C). Compounds 1–6 exhibited acetylcholinesterase (AChE) inhibitory activities with IC50 values ranging from 50.90 to 82.83 µM, whereas 2–6 showed butyrylcholinesterase (BChE) inhibitory activities with IC50 values of 114.75–185.55 µM. Although most of the compounds isolated lacked scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO−), compound 8 showed ONOO− scavenging activity with an IC50 value of 26.23 µg/mL.
著者
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JUNG Hyun
Department of Botanical Resources, Sangji University
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FANG Zhe
College of Pharmacy, Catholic University of Daegu
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Jeong Su
College of Pharmacy, Catholic University of Daegu
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Hee Woo
College of Pharmacy, Catholic University of Daegu
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Sue Choi
Division of Food Science and Biotechnology, Pukyong National University
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Sun Min
College of Pharmacy, Catholic University of Daegu
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Yang Jeong
College of Pharmacy, Catholic University of Daegu
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Ah Jung
Department of Food Science and Human Nutrition, Chonbuk National University
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