S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina(Medicinal Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Amentoflavone, which is a biflavone derived from various plants, has been known to possess various biological activities including anti-tumor and anti-inflammatory activity. In the previous study, we reported antifungal effect of amentoflavone isolated from an ethyl acetate extract of Selaginella tamariscina on human pathogenic fungi. Amentoflavone significantly inhibited the growth of fungal cells without hemolysis of human erythrocytes. In the present study, we investigated antifungal acting mode of amentoflavone in human pathogenic yeast Candida albicans. Anticandidal activity was exerted in an energy-independent manner presented by an antifungal assay in the presence of NaN_3, which is ATP-depleting agent as a metabolic inhibitor. To investigate the effects of amentoflavone on cellular physiology in C. albicans, we performed cell cycle analysis, and the analysis showed that amentoflavone significantly arrested cell cycles during the S-phase. These results demonstrated that amentoflavone has potent anticandidal activity with significant physiological changes inducing S-phase arrest in intracellular environment. Therefore, amentoflavone may be applied to a lead compound for the development of therapeutic agents, which can treat candidiasis resulted from candidal infections.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
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Lee Dong
Department Of Environmental Atmospheric Science Pukyong National University
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Lee In-Seon
The Center for Traditional Microorganism Resources, Keimyung University
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JUNG Hyun
Department of Botanical Resources, Sangji University
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Kim Hyun
The Center For Traditional Microorganism Resources (tmr) Keimyung University
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WOO Eun-Rhan
College of Pharmacy, Chosun University
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Yeo Soo-hwan
Rural Resources Development Institute National Institute Of Agricultural Science And Technology Rura
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Lee In-seon
The Center For Traditional Microorganism Resources (tmr) Keimyung University
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Lee Dong
Department Of Microbiology & Immunology School Of Life Sciences And Biotechnology College Of Nat
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Woo Eun-rhan
College Of Pharmacy Chosun University
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PARK Keunnam
Department of Microbiology & Immunology, School of Life Sciences and Biotechnology, College of Natur
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Park Keunnam
Department Of Microbiology & Immunology School Of Life Sciences And Biotechnology College Of Nat
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Jung Hyun
Department Of Microbiology & Immunology School Of Life Sciences And Biotechnology College Of Nat
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Lee Dong
Department Of Aerospace Engineering Chonbuk National University
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Kim Hyun
The Catholic University Of Korea College Of Medicine
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Lee In-seon
The Center For Traditional Microorganism Resources (tmr) Keimyung Univ.
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