Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae, Ecklonia stolonifera and Eisenia bicyclis
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概要
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The present work investigates protein tyrosine phosphatase 1B (PTP1B) and the α-glucosidase inhibitory activities of two edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, as well as in their isolated phlorotannins. Since the individual extracts and fractions showed significant inhibitory activities, column chromatography was performed to isolate six phlorotannins, phloroglucinol (1), dioxinodehydroeckol (2), eckol (3), phlorofurofucoeckol-A (4), dieckol (5), and 7-phloroeckol (6). Phlorotannins 3–6 were potent and noncompetitive PTP1B inhibitors with IC50 values ranging from 0.56 to 2.64 μM; 4–6 exhibited the most potent α-glucosidase inhibition with IC50 values ranging from 1.37 to 6.13 μM. Interestingly, 4 and 6 were noncompetitive, while 5 exhibited competitive inhibition in an α-glucosidase assay. E. stolonifera and E. bicyclis as well as their isolated phlorotannins therefore possessed marked PTP1B and α-glucosidase inhibitory activities; this could lead to opportunities in the development of therapeutic agents to control the postprandial blood glucose level and thereby prevent diabetic complications.
著者
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JUNG Hyun
Department of Botanical Resources, Sangji University
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Choi Jae
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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Islam Md.
Department Of Advanced Materials Science And Engineering Yamaguchi University
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Moon Hye
Department Of Chemistry Pohang University Of Science And Technology
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AHN Bo
Department of Food Science and Nutrition, Pukyong National University
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CHOWDHURY Sabiha
Department of Food Science and Nutrition, Pukyong National University
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SOHN Hee
Department of Food Science and Human Nutrition, Chonbuk National University
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