Synthesis of Gerfelin and Related Analogous Compounds

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概要

• 論文の詳細を見る

• Gerfelin, an inhibitor of human geranylgeranyl diphosphate (GGPP) synthase that has been isolated from a culture broth of Beauveria felina QN22047, was synthesized in 4 and 3 steps starting from 2,4-dihydroxy-6-methylbenzoic acid and 3,4,5-trihydroxytoluene, respectively. An effective ligand, 2-(di-tert-butylphosphino)biphenyl, was used in the palladium-catalyzed diaryl ether-forming reaction. Five analogous compounds of gerfelin were also synthesized for a study of the structure-activity relationship.

• 社団法人 日本農芸化学会の論文
• 2006-10-23

著者

• ISLAM Md.

  Department of Life Science, Graduate School of Life Science, University of Hyogo

• Kitahara Takeshi

  Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Science The

• WATANABE HIDENORI

  Department of Applied Biological Chemistry, The University of Tokyo

• IMOTO Masaya

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• Islam Md.

  Department Of Advanced Materials Science And Engineering Yamaguchi University

• Imoto M

  Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University

• Imoto Masaya

  Department Of Agricultural Chemistry Faculty Of Agriculture Yamaguchi University

• Islam Md.

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Kitahara T

  The University Of Tokyo

• Kitahara T

  Department Of Agricultural Chemistry The University Of Tokyo

• KITAGAWA Mitsuhiro

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• Kitagawa Mitsuhiro

  Department Of Biosciences And Informatics Faculty Of Science And Technology Keio University

• Watanabe Hidenori

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Momose Isao

  Numazu Bio-medical Research Institute Microbial Chemistry Research Center

• Watanabe Hidenori

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Kitahara Takeshi

  Department Of Agricultural Chemistry The University Of Tokyo

• Kitahara Takeshi

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Watanabe Hidenori

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Biological Sciences T

• Kitahara Takeshi

  School Of Pharmacy Teikyo Heisei Univ.

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