Effect of Methanol Extract of Zanthoxylum piperitum Leaves and of Its Compound, Protocatechuic Acid, on Hepatic Drug Metabolizing Enzymes and Lipid Peroxidation in Rats(Food & Nutrition Science)
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概要
- 論文の詳細を見る
The effect of methanol extract and protocatechuic acid from the leaves of Zanthoxylum piperitum on lipid peroxidation and drug metabolizing enzymes were investigated in the liver of bromobenzene-treated rats. The methanol extract and protocatechuic acid reduced the level of lipid peroxide induced by bromobenzene. The methanol extract and protocatechuic acid reduced the activity of aniline hydroxylase that had been increased by bromobenzene, while did not affect the activities of aminopyrine N-demethylase and glutathione S-transferase. The methanol extract and compound effectively restored the activity of epoxide hydrolase which had been decreased by bromobenzene. These results may suggest that the methanol extract of Z. piperitum and protocatechuic acid prevented lipid peroxidation by reducing the activity of aniline hydroxylase, an epoxide-producing enzyme, and by enhancing the activity of epoxide hydrolase, an epoxide-removing enzyme, in rats that had been intoxicated with bromobenzene.
- 社団法人日本農芸化学会の論文
- 2003-05-23
著者
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PARK Jong
Department of Internal Medicine, Chonnam National University Hospital
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PARK JU
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center
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Choi Jong
Department Of Pharmacy Kyungsung University
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CHOI Jae
Faculty of Food Science and Biotechnology, Pukyong National University
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Park Jeong
Department Of Medicine
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Hur Jong
Department Of Oriental Medicine Resources And Research Institute Of Korean Oriental Medicine
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Hur Jong
Department Of Agricultural Chemistry Division Of Applied Life Science Gyeongsang National University
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Choi Jae
Department Of Electronics Engineering University Of Incheon
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Choi Jae
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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Choi J
Pukyong National Univ. Busan Kor
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Choi Jae
Faculty Of Food Science And Biotechnology Pukyong National University
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Yang Ki
Department Of Pathology National Institute Of Toxicological Research Korea Food Drug Administration
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Yang Ki
Department Of Oriental Medicine Resources And Research Institute Of Korean Oriental Medicine
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Park Jong
Department Of Oriental Medicine Resources And Research Institute Of Korean Oriental Medicine
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CHUN Soon
Department of Food and Nutrition, Sunchon National University
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Park Jeong
Department Of Food And Nutrition Sunchon National University
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Choi Jong
Department Of Archaeology Kyongnam Archaeology Institute
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Yang Ki
Department Of Obstetrics And Gynecology School Of Medicine Kyung Hee University Kyung Hee Medical Ce
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Park Jong
Department Mathematics Pusan National University
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Chun Soon
Department Of Food And Nutrition Sunchon National University
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Park Ju
Department Of Electronics And Computer Engineering Chonnam National University
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Park Jeong
Department Of Biological Sciences University Of Ulsan
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Park Jeong
Department Of Basic Nursing Science And Institute For Nursing Science Keimyung University College Of
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Park Ju
Department Of Dermatology College Of Medicine Hallym University
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Park Ju
Department Of Oriental Medicine Resources And Research Institute Of Korean Oriental Medicine
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