Magnoflorine from Coptidis Rhizoma Protects High Density Lipoprotein during Oxidant Stress(Pharmacognosy)

概要

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The objective of the present study was to investigate the beneficial properties of magnoflorine, an alkaloid isolated from Coptidis Rhizoma, on protecting human high density lipoprotein (HDL) against lipid peroxidation. Magnoflorine exerts an inhibitory effect against Cu^<2+>-induced lipid peroxidation of HDL, as showed by prolongation of lag time from 62 to 123 min at the concentration of 3.0μM. It also inhibits the generation of thiobarbituric acid reactive substances (TBARS) in the dose-dependent maners with IC_<50> values of 2.3±0.2μM and 6.2±0.5μM since HDL oxidation mediated by either catalytic Cu^<2+> or thermo-labile radical initiator (AAPH), respectively. Separately, Cu^<2+> oxidized HDL lost the antioxidant action but the inclusion of magnoflorine/Cu^<2+> oxidized HDL can protect LDL oxidation according to increasing magnoflorine concentration. The results suggest that magnoflorine may have a role to play in preventing the HDL oxidation.
公益社団法人日本薬学会の論文
2007-06-01