Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity

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概要

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• Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC_<50> value of 1.3μ/ml.

• 社団法人日本薬学会の論文
• 2008-01-01

著者

• Youn Uijung

  College Of Pharmacy Chungnam National University

• BAE KiHwan

  College of Pharmacy, Chungnam National University

• BAE Ki

  College of Pharmacy, Chungnam National University

• Bae Ki

  College Of Pharmacy Chungnam National University

• Bae Kihwan

  韓国

• Min Byung-sun

  Coll. Of Pharmacy Catholic Univ. Of Daegu

• Min Byung

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Na MinKyun

  College of Pharmacy, Yeungnam University

• Min Byung-sun

  College Of Pharmacy Catholic University Of Daegu

• Chen Quan

  College Of Pharmacy Chungnam National University

• Bae Kihwan

  College Of Pharmacy Chungnam National University

• YOUN UiJoung

  College of Pharmacy, Chungnam National University

• LEE Ik

  College of Pharmacy, Chungnam National University

• KIM HongJin

  College of Pharmacy, Chungnam National University

• YOO Jae-Kuk

  College of Pharmacy, Chungnam National University

• LEE JongPill

  Korea Food & Drug Administration

• YOO Jae

  College of Pharmacy, Chungnam National University

• Lee Ik

  Coll. Of Pharmacy Chungnam National Univ. Kor

• Lee Ik

  College Of Pharmacy Chungnam National University

• NA Min

  Korea Research Institute of Bioscience and Biotechnology (KRIBB)

• Na Minkyun

  Korea Res. Inst. Of Bioscience And Biotechnology (kribb)

• Na Minkyun

  College Of Pharmacy Chungnam National University

• Yoo Jae

  韓国

• Min Byung-sun

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Min Byung

  Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology

• Kim Hong

  College Of Pharmacy Chungnam National University

• Na Min-kyun

  College Of Pharmacy Chungnam National University

• Lee Iksoo

  College Of Pharmacy Chungnam National University

• Lee Jong-pill

  Korea Food & Drug Administration

• Lee Jongpill

  Korea Food & Drug Administration

• Bae K

  College Of Pharmacy Chungnam National University

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