Asterosaponins Isolated from the Starfish Asterias amurensis
スポンサーリンク
概要
- 論文の詳細を見る
Three new asterosaponins 1—3 and four known saponins 4—7 have been isolated from the starfish Asterias amurensis LÜTKEN. By means of high magnetic field 1D- and 2D-NMR (1H–1H correlation spectroscopy (COSY), total correlation spectroscopy (TOCSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)) and MS analyses, the chemical structures of new compounds were determined to be 6α-O-[β-D-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-quinovopyranosyl-(1→3)-β-D-galactopyranosyl]-5α-chol-9(11)-en-23-one-3β-yl sodium sulfate (1), 6α-O-[β-D-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-quinovopyranosyl-(1→3)-β-D-galactopyranosyl]-5α-cholesta-9(11),24-dien-23-one-3β-yl sodium sulfate (2), and 6α-O-[β-D-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→4)-[β-D-quinovopyranosyl-(1→2)]-β-D-quinovopyranosyl-(1→3)-β-D-galactopyranosyl]-5α-cholest-9(11)-en-23-one-3β-yl sodium sulfate (3). In addition, the NMR data for known saponins 4—7 were completely assigned by extensive 2D-NMR analysis without chemical degradation.
著者
-
CHANG Hyeun
College of Pharmacy, Yeungnam University
-
KIM Cheorl-Ho
Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco
-
SON Jong
College of Pharmacy, Yeungnam University
-
Kim Jin
韓国
-
Son Jong
College Of Pharmacy Yeungnam University
-
LEE Seung
College of Pharmacy, Yeungnam University
-
Son Jong
Coll. Of Pharmacy Yeungnam Univ.
-
Son J
College Of Pharmacy Yeungnam University
-
Chang Hyeun
College Of Pharmacy Yeungnam University
-
Hwang In
College of Pharmacy, Yeungnam University
-
Kim Dong
National Institute of Scientific Investigation, Korea
-
Kim Su
College of Pharmacy, Yeungnam University
-
Min Byung
College of Pharmacy, Catholic University of Daegu
-
Na MinKyun
College of Pharmacy, Yeungnam University
-
Min Byung
College Of Pharmacy Catholic University Of Daegu
-
Na Minkyun
College Of Pharmacy Chungnam National University
-
Kim Cheorl-ho
Department Of Agricultural Chemistry The University Of Tokyo
-
Lee Seung
College Of Pharmacy And Cbitrc Chungbuk National University
-
Kim Su
College Of Pharmacy Seoul National University
-
Hwang In
College of Pharmacy, Duksung Women's University
関連論文
- Effect of Dexamethasone on STAT6-Dependent Ym1/2 Expression in Vivo and in Vitro(Biochemistry)
- Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum(Pharmacology)
- Ochnaflavone, Naturally Occurring Biflavonoid, Inhibits Phospholipase A_2 Dependent Phosphatidylethanolamine Degradation in a CCl_4-Induced Rat Liver Microsome(Biochemistry)
- Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)
- Anti-inflammatory Activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation(Biochemistry)
- Anti-asthmatic Activity of an Ethanol Extract from Saururus chinensis(Biochemistry)
- Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
- Saponins and Other Constituents from the Leaves of Aralia elata
- Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis(Biochemistry/Molecular Biology)
- Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
- Triterpenoid Saponins from the Roots of Sophora koreensis
- Phenolic Glycosides from Pyrola japonica
- Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
- Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)
- Regulatory Effect of Dosiinpartner on High-Fat Diet-Induced Obesity in C57BL/6J Mice(Pharmacology)
- Dual Inhibition of Cyclooxygenases-2 and 5-Lipoxygenase by Deoxypodophyllotoxin in Mouse Bone Marrow-Derived Mast Cells(Biochemistry/Molecular Biology)
- Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages (Biochemistry/Molecular Biology)
- Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
- The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-kB Activation in RAW264.7 Macrophage Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation
- One-Pot Synthesis of Simple Alkaloids : 2,3-Polymethylene-4(3H)-quinazolinones, Luotonin A, Tryptanthrin, and Rutaecarpine
- Rubus croceacanthus Leveille Inhibits Mast Cell-Mediated Anaphylactic-Like Reaction and Tumor Necrosis Factor-α Secretion(Pharmacology)
- Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
- Asterosaponins Isolated from the Starfish Asterias amurensis
- Flavonoid Glycosides from Chromolaena odorata Leaves and Their in Vitro Cytotoxic Activity
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
- Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
- Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
- Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
- 2-Hydroxycinnamaldehyde Inhibits SW620 Colon Cancer Cell Growth Through AP-1 Inactivation
- In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- Anti-amnestic Activity of Pseudocoptisine from Corydalis Tuber(Pharmacognosy)
- Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity
- Cytotoxicity of Triterpenes Isolated from Aceriphyllum rossii
- Anticancer Constituents from the Roots of Rubia cordifolia L.
- Increase of Caspase-3 Activity by Lignans from Machilus thunbergii in HL-60 Cells(Pharmacognosy)
- Effects of Oleanane-Type Triterpenoids from Fabaceous Plants on the Expression of ICAM-1
- Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection
- Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells(Molecular and Cell Biology)
- Protective Effect of Puerariae Radix on Oxidative Stress Induced by Hydrogen Peroxide and Streptozotocin(Molecular and Cell Biology)
- Antioxidant Activity of Jionoside D from Clerodendron trichotomum(Biochemistry/Molecular Biology)
- Iridoid Esters from Patrinia saniculaefolia
- Detection and Characterization of a Type IIA Secretory Phospholipase A_2 Inhibitory Protein in Human Amniotic Fluid
- cDNA Cloning and Expression of Biologically Active Platelet Activating Factor-Acetylhydrolase (PAF-AH) from Bovine Mammary Gland(Biochemistry/Molecular Biology)
- DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-α Production
- Action of Dracocephalum argunense on Mast Cell-Mediated Allergy Model(Pharmacognosy)
- Inhibitory effect of a traditional Chinese formulation, Hyul-Tong-Ryung, on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells
- Proteome Profiling of U2OS Cell Line in Response to a Prenylphenol Antibiotic Isolated from a Phytopathogenic Fungus(Molecular and Cell Biology)
- Effect of Herbal Medicines on Cytokine-Induced Cytotoxicity and Major Histocompatibility Complex (MHC) Class II Antigen Expression in Rat Thyroid Cells (Pharmacognosy)
- Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor κB and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264.7 Cells
- A New Naphthopyrone from the Root of Pleuropterus ciliinervis
- Inhibition of Human Low Density Lipoprotein and High Density Lipoprotein Oxidation by Oligostilbenes from Rhubarb(Pharmacognosy)
- Effect of Astilbe koreana on Ultraviolet B (UVB)-Induced Inflammatory Response in Human Keratinocytes(Pharmacognosy)
- Triterpenoid Saponins from the Seeds of Pharbitis nil
- Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum(Pharmacognosy)
- Norditerpenoid Alkaloids from the Processed Tubers of Aconitum carmichaeli
- Ginsenosides from Heat Processed Ginseng
- Magnoflorine from Coptidis Rhizoma Protects High Density Lipoprotein during Oxidant Stress(Pharmacognosy)
- Inhibitory Effect of Coumarins from Weigela subsessilis on Low Density Lipoprotein Oxidation(Pharmacognosy)
- A New Acylated Triterpene from the Roots of Chaenomeles japonica
- Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba(Pharmacognosy)
- Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
- New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
- Enhanced differentiation of mesenchymal stem cells into NP-like cells via 3D co-culturing with mechanical stimulation(CELL AND TISSUE ENGINEERING)
- Inhibition of Prostaglandin Production by a Structurally-Optimized Flavonoid Derivative, 2',4',7-Trimethoxyflavone and Cellular Action Mechanism(Biochemistry)
- Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Kaempferol Acetylrhamnosides from the Rhizome of Dryopteris crassirhizoma and Their Inhibitory Effects on Three Different Activities of Human Immunodeficiency Virus-1 Reverse Transcriptase
- Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines
- Increase of collagen synthesis by obovatol through stimulation of the TGF-β signaling and inhibition of matrix metalloproteinase in UVB-irradiated human fibroblast
- Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
- Change in Action Pattern of Bacillus circulans F-2 Amylase on Partial Hydrolysis with Subtilisin(Biological Chemistry)
- Protective role of Bcl-2 on β-amyloid-induced cell death of differentiated PC12 cells : reduction of NF-κB and p38 MAP kinase activation
- Mushroom Tyrosinase Inhibition Activity of Some Chromones
- Protective Mechanism of Glycyrrhizin on Acute Liver Injury Induced by Carbon Tetrachloride in Mice(Pharmacology)
- Gallotannin Isolated from Euphorbia Species, 1,2,6-Tri-O-galloyl-β-D-allose, Decreases Nitric Oxide Production through Inhibition of Nuclear Factor-κ>B and Downstream Inducible Nitric Oxide Synthase Expression in Macrophages
- Purification and Characterization of 45 kDa PAF Acetylhydrolase from Bovine Colostrum(Biochemistry)
- Spontaneous Ultraweak Photon Emission during the Growth of the Cell Population of Cultured HeLa Cell Line
- Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury
- Testosterone 5α-Reductase Inhibitors, Menaquinone 7 Produced by a Bacillus and Phenazine Methosulfate
- New Method for Contact Patterning of High-Efficiency Solar Cells using a Mechanical Scriber
- Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
- Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of Dioscorea batatas Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells
- Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
- Anticholinesterase and Antioxidant Constituents from Gloiopeltis furcata
- Spontaneous Ultra-Weak Photon Emission and Delayed Luminescence during Carbon Tetrachloride-Induced Liver Injury and Repair in Mouse
- Luteolin-7-O-glucoside Suppresses Leukotriene C4 Production and Degranulation by Inhibiting the Phosphorylation of Mitogen Activated Protein Kinases and Phospholipase Cγ1 in Activated Mouse Bone Marrow-Derived Mast Cells
- α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)-Inducible Inflammatory Genes in Interferon-γ-Stimulated Macrophages
- Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines
- Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
- Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells
- Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells
- Pinusolide Isolated from Biota orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells
- Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells
- Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-.ALPHA. in Murine Lung Epithelial Cells