Inhibitory Effect of Coumarins from Weigela subsessilis on Low Density Lipoprotein Oxidation(Pharmacognosy)
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概要
- 論文の詳細を見る
Oxidation of low density lipoprotein (LDL) is thought to be a major factor in the pathophysiology of atherosclerosis. In the present study, we found that coumarins isolated from Weigela subsessilis (Caprifoliaceae) inhibited LDL oxidation mediated by either catalytic copper ions (Cu^<2+>) or free radicals generated with the azo compound 2,2′-azobis-(2-amidinopropane) dihydrochloride (AAPH). Of the coumarins tested, scopoletin (1) and cleomiscosin A (2) increased the lag time of conjugated diene formation and inhibited the generation of thiobarbituric acid reactive substances (TBARS) in a dose-dependent manner. In addition, it was found that compounds 1 and 2 had the capacity to protect the fragmentation of apolipoprotein B-100 (apoB-100). These results suggest that W. subsessilis and its active coumarins, 1 and 2, may have a role to play in preventing the LDL oxidation involved in atherogenesis.
- 公益社団法人日本薬学会の論文
- 2005-06-01
著者
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BAE KiHwan
College of Pharmacy, Chungnam National University
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BAE Ki
College of Pharmacy, Chungnam National University
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Thuong Phuong
Vietnam National Inst. Of Medicinal Materials
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Thuong Phuong
College Of Pharmacy Chungnam National University
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Thuong Phuong
College Of Pharmacy Chosun University
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Bae Ki
College Of Pharmacy Chungnam National University
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Bae Kihwan
韓国
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LEE Young
College of Veterinary Medicine, Seoul National University
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Na MinKyun
College of Pharmacy, Yeungnam University
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Seong Rack
Korea Food & Drug Administration
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Bae Kihwan
College Of Pharmacy Chungnam National University
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NA Min
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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SOK Dai
College of Pharmacy, Chungnam National Unversity
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Na Minkyun
Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Na Minkyun
College Of Pharmacy Chungnam National University
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Su Nguyen
College of Pharmacy, Chungnam National University
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Na Min-kyun
College Of Pharmacy Chungnam National University
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Sok Dai
College Of Pharmacy Chungnam National University
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Su Nguyen
College Of Pharmacy Chungnam National University
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Lee Young
College Of Bioscience Institute Of Biotechnology Department Of Bioscience And Biotechnology Sejong U
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Bae K
College Of Pharmacy Chungnam National University
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LEE Young
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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