Triterpenoids from Camellia japonica and Their Cytotoxic Activity
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概要
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From the ethyl acetate fraction of the stem bark of Camellia japonica, three new triterpenoids, 3β-O-acetyl-16β-hydroxy-12-oxoolean (6), 3β-O-acetyl-16β-hydroxy-11-oxoolean-12-ene (7), and 3β-O-acetyl-16β-hydroxyolean-12-ene (8), along with seven known compounds, 3α-hydroxy-1-oxofriedelan (1), friedelin (2), 3β-friedelanol (3), canophyllol (4), 3-oxofriedelan-1(2)-ene (5), β-amyrin (9), camellenodiol (10), and camelledionol (11) were isolated. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The isolated compounds were tested in vitro for their cytotoxic activities against the A549, LLC, HL-60 and MCF-7 cancer cell lines. Among them, compound 8 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 25.2 and 21.7 μM, respectively.
著者
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Bae Kihwan
College Of Pharmacy Chungnam National University
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Hung Tran
College Of Pharmacy Catholic University Of Daegu
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Kim Jin
Korea Advanced Inst. Sci. And Technol. Daejeon Kor
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Lee Mi
College of Pharmacy and Medical Research Center, Chungbuk National University
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Thao Nguyen
College of Pharmacy, Chungnam National University
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Kim Jin
Korea Research Institute of Chemical Technology
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