Neuroprotective Effect of Smilacis chinae Rhizome on NMDA-Induced Neurotoxicity In Vitro and Focal Cerebral Ischemia In Vivo

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概要

• 論文の詳細を見る

• Previous work has shown that the Smilacis chinae rhizome (SCR) markedly inhibits amyloid β protein (25-35)–induced neuronal cell damage in cultured rat cortical neurons. The present study was conducted to further verify the neuroprotective effect of SCR on excitotoxic and cerebral ischemic injury using both in vitro and in vivo studies. Exposure of cultured cortical neurons to 1 mM N-methyl-<sc>D</sc>-aspartate (NMDA) for 12 h induced neuronal cell death. SCR (10 and 50 μg/ml) inhibited NMDA-induced neuronal death, elevation of intracellular calcium ([Ca2+]i), and generation of reactive oxygen species (ROS) in primary cultures of rat cortical neurons. In vivo, SCR prevented cerebral ischemic injury induced by 3-h middle cerebral artery occlusion (MCAO) and 24-h reperfusion. The ischemic infarct was significantly reduced in rats that received SCR (30 and 50 mg/kg, orally), with a corresponding improvement in neurological function. Moreover, SCR treatment significantly decreased the histological changes observed following ischemia. Oxyresveratrol and resveratrol isolated from SCR also inhibited NMDA-induced neuronal death, increase in [Ca2+]i, and ROS generation in cultured cortical neurons, suggesting that the neuroprotective effect of SCR may be attributable to these compounds. Taken together, these results suggest that the neuroprotective effect of SCR against focal cerebral ischemic injury is due to its anti-excitotoxic effects and that SCR may have a therapeutic role in neurodegenerative diseases such as stroke.

• 社団法人 日本薬理学会の論文
• 2008-01-20

著者

• KIM Ju

  College of Veterinary Medicine, Chungbuk National University

• JU Hyun

  College of Veterinary Medicine, Chungbuk National University

• SONG Kyung-Sik

  College of Agriculture and Life-Science, Kyungpook National University

• SEONG Yeon

  College of Veterinary Medicine, Chungbuk National University

• BAN Ju

  College of Veterinary Medicine, Chungbuk National University

• CHO Soon

  College of Veterinary Medicine, Chungbuk National University

• BAE KiHwan

  College of Pharmacy, Chungnam National University

• Song Kyung-sik

  College Of Agriculture And Life-sciences Kyungpook National University

• Song Kyung-sik

  韓国

• Bae Ki

  College Of Pharmacy Chungnam National University

• Bae Kihwan

  韓国

• Kim Ju

  College Of Veterinary Medicine Chungbuk National University

• Cho Soon

  College Of Veterinary Medicine Chungbuk National University

• Bae Kihwan

  College Of Pharmacy Chungnam National University

• Seong Yeon

  Coll. Of Veterinary Medicine Chungbuk National Univ. Kor

• Ban Ju

  School Of Dentistry Dankook University

• Ban Ju

  College Of Veterinary Medicine And Research Institute Of Herbal Medicine Chungbuk National Universit

• CHOI Sun-Ha

  College of Agriculture and Life-Sciences, Kyungpook National University

• Ju Hyun

  College Of Veterinary Medicine Chungbuk National University

• Choi Sun-ha

  College Of Agriculture And Life-sciences Kyungpook National University

• Seong Y

  College Of Agriculture And Life Science Kyungpook National University

• Seong Yeon

  College Of Agriculture And Life Science Kyungpook National University

• Kim Ju

  College Of Pharmacy Yeungnam University

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