Cytotoxicity of Triterpenes Isolated from Aceriphyllum rossii
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概要
- 論文の詳細を見る
Bioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3α-hydroxyolean-12-en-27-oic acid (4), β-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1-6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC_<50> values ranging from 12.2 to 28.7μM and from 12.1 to 25.8μM, respectively.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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Youn Uijung
College Of Pharmacy Chungnam National University
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SEONG Yeon
College of Veterinary Medicine, Chungbuk National University
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BAE KiHwan
College of Pharmacy, Chungnam National University
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Song Kyung
College Of Agriculture And Life Science Kyungpook National University
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BAE Ki
College of Pharmacy, Chungnam National University
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Bae Ki
College Of Pharmacy Chungnam National University
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Bae Kihwan
韓国
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Min Byung-sun
Coll. Of Pharmacy Catholic Univ. Of Daegu
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Min Byung
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Min Byung
College of Pharmacy, Catholic University of Daegu
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Na MinKyun
College of Pharmacy, Yeungnam University
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Chen Quan
College Of Pharmacy Chungnam National University
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Bae Kihwan
College Of Pharmacy Chungnam National University
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Seong Yeon
Coll. Of Veterinary Medicine Chungbuk National Univ. Kor
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KIM HongJin
College of Pharmacy, Chungnam National University
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LEE JongPill
Korea Food & Drug Administration
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LEE IkSoo
College of Pharmacy, Chungnam National University
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YOO Jae
College of Pharmacy, Chungnam National University
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YUN Bong
Korea Research Institute of Bioscience and Biotechnology
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JIN WenYi
College of Pharmacy, Chungnam National University
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Min Byung
College Of Pharmacy Catholic University Of Daegu
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Lee Ik
Coll. Of Pharmacy Chungnam National Univ. Kor
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NA Min
Korea Research Institute of Bioscience and Biotechnology (KRIBB)
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Na Minkyun
Korea Res. Inst. Of Bioscience And Biotechnology (kribb)
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Na Minkyun
College Of Pharmacy Chungnam National University
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Yoo Jae
韓国
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Song Kyung
Coll. Of Agriculture And Life Sci. Kyungpook National Univ.
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Min Byung-sun
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Seong Y
College Of Agriculture And Life Science Kyungpook National University
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Yoo Jae
College Of Pharmacy Chungnam National University
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Seong Yeon
College Of Agriculture And Life Science Kyungpook National University
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Min Byung
Laboratory Of Immunomodulator Korea Research Institute Of Bioscience And Biotechnology
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Jin Wenyi
College Of Pharmacy Chungnam National University
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Kim Hong
College Of Pharmacy Chungnam National University
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Na Min-kyun
College Of Pharmacy Chungnam National University
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Lee Iksoo
College Of Pharmacy Chungnam National University
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Lee Jong-pill
Korea Food & Drug Administration
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Lee Jong
Korea Food And Drug Administration
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Bae K
College Of Pharmacy Chungnam National University
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