Flavonoid Glycosides from Chromolaena odorata Leaves and Their in Vitro Cytotoxic Activity

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概要

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• Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3—13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC50 value of 10.8 μM.

著者

• Zhu Shu

  Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine University

• Komatsu Katsuko

  Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers

• Min Byung

  College of Pharmacy, Catholic University of Daegu

• HUNG Tran

  College of Pharmacy, Chungnam National University

• Min Byung

  College Of Pharmacy Catholic University Of Daegu

• DANG Nguyen

  Institute of Natural Product Chemistry, Vietnamese Academy of Science and Technology

• Cuong To

  College of Pharmacy, Catholic University of Daegu

• Long Pham

  Institute of Natural Product Chemistry, Vietnamese Academic of Science and Technology

• Komatsu Katsuko

  Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med

• Hung Tran

  College Of Pharmacy Catholic University Of Daegu

• Dang Nguyen

  Institute Of Ecology And Biological Resources Vietnam Academy Of Science And Technology

• Zhu Shu

  Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

• Zhu Shu

  Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

• Komatsu Katsuko

  Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

• Komatsu Katsuko

  Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama

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