Prediction of Cyclooxygenase Inhibitory Activity of Curcuma Rhizome from Chromatograms by Multivariate Analysis
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概要
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The potential use of partial least square regression (PLS-R) models for the prediction of biological activities of a herbal drug based on its liquid chromatography (LC) profile was verified using various extracts of Curcuma phaeocaulis and their cyclooxygenase-2 (COX-2) inhibitory activities as the model experiment. The correlation of practically measured inhibitory activities and predicted values by PLS-R analysis was quite good (correlation coefficient=0.9935) and the possibility of transforming chromatographic information into a measure of biological activity was confirmed. In addition, furanodienone and curcumenol were identified as the major active anti-inflammatory constituents of C. phaeocaulis, through detailed analysis of the regression vector, followed by isolation of these compounds and their COX-2 inhibitory assays. The selectivity indices (SI), IC_<50> of COX-1/IC_<50> of COX-2, of both compounds were higher than that of indomethacin and it is considered that furanodienone and curcumenol are the most promising compounds as lead anti-inflammatory agents.
- 社団法人日本薬学会の論文
- 2008-07-01
著者
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WATANABE Hiroshi
International Research Center for Traditional Medicine, Toyama Prefecture International Health Compl
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Tanaka Ken
Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers
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Komatsu Katsuko
Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers
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Ina Atsutoshi
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine University
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KUBA Yoshiaki
Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, Univers
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Kuba Yoshiaki
Institute Of Natural Medicine University Of Toyama
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Komatsu Katsuko
富山大学和漢医薬学総合研究所
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Komatsu K
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Komatsu K
Institute Of Natural Medical Toyama Medicine And Pharmaceutical University
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Komatsu Katsuko
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine Toyama Med
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Komatsu Katsuko
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Komatsu Katsuko
Division Of Pharmacognosy Institute Of Natural Medicine University Of Toyama
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Komatsu K
Institute Of Natural Medicine University Of Toyama
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Tanaka Ken
Div. Of Pharmacognosy Dep. Of Medicinal Resources Inst. Of Natural Medicine Univ. Of Toyama
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Tanaka Ken
Division Of Pharmacognosy Department Of Medicinal Resources Institute Of Natural Medicine University
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Komatsu Katsuko
Division of Parmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
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