Pharmacological Properties of Traditional Medivines. XXV. Effects of Ephedrine, Amygdalin, Glycyrrhizin, Gypsum and Their Combinations on Body Temperature and Body Fluid
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概要
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Effects of ephedrine, amygdalin, glycyrrhizin, gypsum and their combinations on body temperature and body fluid were studied in rats using the method developed in our previous reports. Ephedrine significantly increased respiratory evaporative water loss and heat loss in response to a marked elevation of body temperature. There was a small but significant increase in body temperature when amygdalin was orally given rats at a dose of 46.32 mg/kg. Glycyrrhizin and gypsum were unable to affect body temperature. However, gypsum was able to prevent the increased action of ephedrine on body temperature, amygdalin exhibited a preventive tendency to it, and glycyrrhizin did not affect it. The results are in good agreement with classical claims of Makyo-kanseki-to (麻杏甘石湯) and the related crude drugs in traditional medicine. Moreover, a combination of the four components reproduced the effects of Makyo-kanseki-to on body temperature and body fluid.This report ssuggests that the co-administration of ephedrine and gypsum is physiologically more desirable than ephedrine alone for dry-type asthmatic patients with a fever. Also, it experimentally supports the clinical efficacy of Makyo-kanseki-to.
- 公益社団法人日本薬学会の論文
- 1999-02-15
著者
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Zhang Chun-ling
China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Kano Y
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Yuan Dan
Department Of Traditional Chinese Medicinal Sciences Shenyang Pharmaceutical University
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CUI Zheng
Department of Pharmacognosy, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical U
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Komatsu Katsuko
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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KOMATSU Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Yuan Dan
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
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Cui Z
Department Of Pharmacognosy School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Uni
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Komatsu Ken-ichi
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Cui Zheng
Department Of Pathology Wake Forest University School Of Medicine
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Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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