Interaction between 3,4,5-trimethoxycinnamic acid and spinosin on pentobarbital-induced sleeping time in mice
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概要
- 論文の詳細を見る
我々は遠志と酸棗仁の水抽出エキスをラットに経口投与した後の血中から,それぞれ3,4,5-trimethoxy cinnamicacid(TMCA)とsninosinを同定し,それらがマウスのhexobarbital誘発睡眠時間を延長することを確認した。そこで,pentobarbital (PB)誘発睡眠時間におけるTMCAとspinosinの相互作用を非ストレスあるいはストレス動物を使って検討した。反復低温ストレスを負荷したマウスのPB睡眠時間は,非ストレスマウスのPB睡眠時間より有意に短縮した。Diazepamは0.5mg/kgの投与量で非ストレスマウスのPB睡眠時間を有意に延長し,ストレスにより短縮したPB睡眠時間をO.1mg/kgで延長した。TMCAは200mg/kgの投与量で非ストレスマウスのPB睡眠時間を延長し,1OOmg/kgでストレスにより短縮したPB睡眠時間を有意に延長した。Spinosinは100mg/kgの投与量で非ストレスマウスのPB睡眠時間を有意に延長し,50mg/kgでストレスにより短縮したPB睡眠時間を有意に延長した。TMCA(25mg/kg)とspinosin(12.5mg/kg)の併用では,非ストレスマウスのPB睡眠時間を有意に延長した。ストレスマウスでは非ストレスマウスの半量の併用で短縮したPB睡眠時間を有意に延長した。本論文で述べた結果は,TMCAとspinosinの併用は鎮静作用においてそれらの各単独投与より効果的であろうということを示す。
- 和漢医薬学会の論文
- 2003-10-20
著者
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Saito K
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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KAWASHIMA Keiko
Department of Kampo Medicinal Science, Hokkaido Pharmacutical University
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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MIYAKO Daishi
Department Kampo Medicinal Science, Hokkaido College of Pharmacy
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Miyako Daishi
Department Kampo Medicinal Science Hokkaido College Of Pharmacy
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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川嶋 恵子
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Sakoda K
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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