Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
スポンサーリンク
概要
- 論文の詳細を見る
Si-Wu-Tang (SWT), a traditional Chinese formula, has been clinically used in the treatment of cutaneous pruritus, chronic inflammation, and other diseases. The present study was carried out to observe the antipruritic and antiinflammatory effects of SWT aqueous extract using compound 48/80 and picryl chloride (PC) models in mice. SWT (500, 1000 mg/kg p.o.) clearly reduced the scratching responses elicited by compound 48/80 in normal mice. At doses of 250 and 500 mg/kg, it inhibited the scratching responses induced by PC in mice actively sensitized with 2,4-dinitrophenol (DNP)-ovalbumin (OVA) plus alum. Furthermore, SWT (250, 500, 1000 mg/kg) significantly inhibited the footpad swelling caused by compound 48/80 in mice. In the biphasic ear skin reactions induced by PC in actively sensitized mice, SWT (250, 500 mg/kg) reduced the immediate-phase reaction, but did not affect the late-phase reaction. In vitro, SWT (50-500 μg/ml) showed a concentration-dependent inhibition of the histamine release induced by compound 48/80 from rat peritoneal mast cells. The crude drugs contained in SWT, Paeoniae Radix (25, 100 μg/ml), Rehmanniae Radix, and Chuanxiong Rhizoma (100 /μg/ml), also showed a clear inhibition, but Angelica Radix did not at the concentrations examined. These findings indicate that SWT aqueous extract has antipruritic and antiinflammatory effects in mice. SWT inhibits histamine release from rat mast cells, and Paeoniae Radix probably plays a crucial role in the formula.
- 社団法人日本薬学会の論文
- 2002-09-01
著者
-
角谷 真
京都薬科大学
-
Matsuda Hideaki
Faculty of Pharmacy, Kinki University
-
Kubo M
School Of Pharmaceutical Sciences Kinki University
-
Kubo Michinori
近畿大学 薬学部
-
DAI Yue
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University
-
BUT Paul
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
-
CHAN Yiu-Pong
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
-
KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
-
Chan Y‐p
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
-
Chan Yiu-pong
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hong Kong
-
Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
-
But P
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
-
Kubo Michinori
Kyoto Pharmaceutical University
-
Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
-
Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
-
Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
-
Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
-
But P
Institute Of Chinese Medicine The Chinese University Of Hong Kong
-
Dai Y
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
-
Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
-
Dai Yue
Department Of Pharmacology Of Chinese Materia Medica China Pharmaceutical University
-
But Paul
Department Of Biochemistry The Chinese University Of Hong Kong
-
Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
-
Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
-
Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
-
Dai Yue
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong:Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University
関連論文
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- P-469 ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF 1'S-1'-ACETOXYCHAVICOL ACETATE AND RELATED COMPOUNDS
- Medicinal Foodstuffs. III. Sugar Beet. (1) : Hypoglycemic Oleanolic Acid Oligoglycosides, Betavulgarosides, I, II, III, and IV, from the Root of Beta vulgaris L. (Chenopodiaceae)
- Effects of Unripe Citrus hassaku Fruits Extract and Its Flavanone Glycosides on Blood Fluidity
- Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice
- Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement
- Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus III. Antinociceptive and Antiinflammatory Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese Kochia scoparia (Chenopodiaceae) : Chemical Structures of Kochianosides I, II, III, and IV
- Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
- Anti-allergic Effects of Cnidii Monnieri Fructus (Dried Fruits of Cnidium monnieri) and Its Major Component, Osthol
- Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)
- Studies on Alismatis Rhizoma. III. Stereostructures of New Protostane-Type Triterpenes, Alisols H, I, J-23-Acetate, K-23-Acetate, L-23-Acetate, M-23-Acetate, and N-23-Acetate, from the Dried Rhizome of Alisma orientale
- Studies on Alismatis Rhizoma. II. Anti-complementary Activities of Methanol Extract and Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
- Antinociceptive Activities of 70% Methanol Extract of Evodiae Fructus(Fruit of Evodia rutaecarpa var.bodinerri) and Its Alkaloidal Components.
- NOVEL iNDOLE S, O-BISDESMOSIDE, CALANTHOSIDE, THE PRECURSOR GLYCOSIDE OF TRYPTANTHRIN, INDIRUBIN, AND ISATIN, WITH INCREASING SKIN BLOOD FLOW PROMOTING EFFECTS, FROM TWO CALANTHE SPECIES (ORCHIDACEAE)
- Studies on Alismatis Rhizoma. I. Anti-allergic effects of Methanol Extract and Six Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
- Antinociceptive Activities of 70% methanol Extract of Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components
- Studies of Cuticle Drugs from Natural Sources. IV. Inhibitory Effects of Some Arctostaphylos Plants on Melanin Biosynthesis
- Phagocytic Activity of Leaves of Epimedium Species on Mouse Reticuloendotherial System
- 薬用食物(第11報) : 冬瓜(Benincasa hispida COGN.)のヒスタミン遊離抑制成分
- 19 薬用食物サトウダイコン(Beta vulgaris,根)の糖吸収抑制成分 : Betavulgaroside類の絶対構造と合成研究(口頭発表の部)
- Bioactive Saponins and Glycosides. I. Senegae Radix. (1) : E-Senegasaponins a and b and Z-Senegasaponins a and b, Their Inhibitory Effect on Alcohol Absorption and Hypoglycemic Activity
- E-SENEGASAPONINS A AND B, Z-SENEGASAPONINS A AND B, Z-SENEGINS II AND III, NEW TYPE INHIBITORS OF ETHANOL ABSORPTION IN RATS FROM SENEGAE RADIX, THE ROOTS OF POLYGALA SENEGA L. VAR LATIFOLIA TORREY ET GRAY
- Inhibitory Effects of Dehydrocorydaline Isolated from Corydalis Tuber against Type I-IV Allergic Models
- Anti-inflammatory Activities of 70% Methanolic Extract from Cinnamomi Cortex
- Studies on Palauan Medicinal Herbs II : Activation of Mouse Macrophages RAW 264.7 by Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL. and Its Acylglucosylsterols(Pharmacognosy)
- Studies on Palauan Medicinal Herbs. I. Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL
- Pharmacological Study on Agkistrodon blomhoffii blomhoffii BOIE. V. Anti-fatigue Effect of the 50% Ethanol Extract in Acute Weight-Loaded Forced Swimming-Treated Rats
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- Anti-proliferative effect of Ginseng Radix on human premyelocytic leukemia cells (HL-60)
- Bioactive Constituent of Notopterygii Rhizoma, Falcarindiol having Antibacterial Activity against Staphylococcus aureus isolated from Patients with Atopic Dermatitis
- Inhibition of Immediate Allergic Reactions by Ethanol Extract from Plumbago zeylanica Stems (Pharmacognosy)
- Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway
- Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
- Inhibitory Activity of Flavonoids and Tannins against HIV-1 Protease
- Antiallergic and Anti-inflammatory Properties of the Ethanolic Extract from Gleditsia sinensis
- Bioactive Saponins and Glycosides. II. Senegae Radix. (2) : Chemical Structures, Hypoglycemic Activity, and Ethanol Absorption-Inhibitory Effect of E-Senegasaponin c, Z-Senegasaponin c, and Z-Senegins II, III, and IV
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents(Pharmacognosy)
- Anti-androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium japonicum)I. : Active Constituents Inhibiting Testosterone 5α-Reductase
- Antipruritic Effect of Cnidii Monnieri Fructus : (Fruits of Cnidium monnieri Cusson)
- Testosterone 5α-Reductase Inhibitory Active Constituents from Anemarrhenae Rhizoma
- Anti-androgenic Activity of Myricae Cortex-Isolation of Active Constituents from Bark of Myrica rubra
- Effects of Chinese Medicine on Morphological Changes in the Intestinal Villi with Age
- A New Cytotoxic Polyhydroxysterol from Soft Coral Sarcophyton trocheliophorum
- Selaginellin A and B, Two Novel Natural Pigments Isolated from Selaginella tamariscina
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Uncinoside A and B, Two New Antiviral Chromone Glycosides from Selaginella uncinata
- Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on Intracellular Ca^ Mobilization in C6 Rat Glioma Cells
- An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)
- Alleviation of Picryl Chloride-Induced Delayed Type Hypersensitivity Reaction by Saponin Fraction of Gleditsia sinensis(Pharmacognosy)
- Medicinal Foodstuffs. IX. The Inhibitors of glucose Absorption from the Leaves of Gymnema sylvestre R. BR. (Asclepiadaceae) : Structures of Gymnemosides a and b
- Pharmacological Properties of Traditional Medivines. XXV. Effects of Ephedrine, Amygdalin, Glycyrrhizin, Gypsum and Their Combinations on Body Temperature and Body Fluid
- Pharmacological Properties of Traditional Medicines. XXIV. Classification of Antiasthmatics Based on Constitutional Predispositions
- In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents
- A Novel 1 : 1 Complex of Potassium Mikanin-3-O-sulfate with Methanol
- Antioxidative Glucosides from the Fruits of Ligustrum lucidum
- Antiviral Amentoflavone from Selaginella sinensis
- A New Anti-HIV Triterpene from Geum japonicum
- Inhibition of Experimental Allergic Rhinitis by the n-Butanol Fraction from the Anomalous Fruits of Gleditsia sinensis
- Determination of scopoletin in rat plasma by high performance liquid chromatographic method with UV detection and its application to a pharmacokinetic study
- Saponins of Plants of Panax Species Collected in Central Nepal and Their Chemotaxonomical Significance. II
- A New Experimental Device for the Measurement of Moisture Emission and Heat Release from Respiratory Organs and Body Surface
- Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedicinal Preparations
- Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages
- Xanthine Oxidase Inhibitory Activities and Crystal Structures of Methoxyflavones from Kaempferia parviflora Rhizome
- Medicial Foodstuffs. XV. Sugar Beet. (2) : Structures of Betavulgarosides V, VI, VII, VIII, IX and X from the Roots and Leaves of Sugar Beet (Beta vulgaris L., Chenopodiaceae)
- Studies on Rehmanniae Radix. V. 5-Hydroxymethyl-2-furaldehyde, Active Constituent of the Steamed Root of Rehmannia glutinosa Having Increasing Activity of Erythrocyte Deformability in Rats
- Studies on Palauan Medicinal Herbs. I. : Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL.
- Effect of geraniin on aminonucleoside nephrosis in rats
- Effects of geraniin on the liver in rats II : liver drug-metabolizing enzymes
- Hematological effect of geraniin in rat
- Effects of Chinese Medicine on Morphological Changes in the Intestinal Villi with Age
- Anti-Inflammatory Activities of Dehydrocorydaline Isolated from Corydalis Tuber
- Bioactive Constituent of Notopterygii Rhizoma, Falcarindiol having Antibacterial Activity against Staphylococcus aureus isolated from Patients with Atopic Dermatitis
- Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MS^n
- Antinociceptive and Antiinflammatory Activities of Evodiamine and Rutaecarpine
- Effects of 70% Methanol Extract from Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components on Blood Circulation
- Anti-allergic Activities of 70% Methanol Extract of Evodiae Fructus (Fruits of Evodia rutaecarpa var. bodinieri) and Its Components
- Anti-tumor Activity of Hot-water Extract of Hericium erinaceum (Bull.:Fr.) Pers. (Yamabushitake)
- NEW HYPOGLYCEMIC CONSTITUENTS IN "GYMNEMIC ACID" FORM GYMNEMA SYLVESTRE
- Pharmacological Study on Panax ginseng C.A. MEYER V. : Effects of Red Ginseng on the Experimental Disseminated Intravascular Coagulation (4). On Ginsenoside-Rg3, Rh1 and Rh2
- Studies on Moutan Cortex (VII) : Inhibitory Effects on Histamine Release from Rat Peritoneal Mast Cells In Vitro
- Inhibitory Effects of Morinda citrifolia Extract and Its Constituents on Melanogenesis in Murine B16 Melanoma Cells
- Matrix Metalloproteinase-1 Inhibitory Activities of Morinda citrifolia Seed Extract and Its Constituents in UVA-Irradiated Human Dermal Fibroblasts
- Studies on Scutellariae Radix (VIII) : Anti-thrombic Actions of 70% Methanolic Extract and Various Fractions from Scutellariae Radix