Effects of geraniin on the liver in rats II : liver drug-metabolizing enzymes
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概要
- 論文の詳細を見る
The effects of geraniin extracted from Geranium hunbergii Sieb. et Zucc. on liver drug-metabolizing enzymes were examined. Treatment with geraniin (Ger) did not affect the activity of succinate cytochrome c reductase, a marker enzyme of mitochondria, nor of 5'-nucleotidase, a marker enzyme of membrane, but lowered the activities of NADPH-cytochrome c reductase and glucose-6-phosphatase in liver homogenate and microsomes, and the cytochrome P450 content in microsome, significantly. It also inhibited the increases in the cytochrome P450 content and the NADPH-cytochrome c reductase activity induced by the phenobarbital treatment. The microsomes of rats treated with Ger reduced the production of lipid peroxide induced by CCl_4. Ger also suppressed the lipid peroxide level induced by CCl_<4> and microsomes of normal rat in vitro.
- 日本生薬学会の論文
- 1998-10-20
著者
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Nakanishi Y
Kinki Univ. Osaka Jpn
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Okuda T
Okayama Univ. Okayama Jpn
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Okuda Takuo
Faculty Of Pharmaceutical Sciences Okayama University
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Abe Hiroko
First Department Research Institute Of Oriental Medicine Kinki University
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Abe Hiroko
Research Institute Of Oriental Medicine Kinki University
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NAKANISHI Yuka
Research Institute of Oriental Medicine Kinki University
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Kubo M
Faculty Of Pharmaceutical Sciences Kinki University
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Okuda Takuo
Faculty of Pharmaceutical Science, Okayama University
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