Anti-allergic Activities of 70% Methanol Extract of Evodiae Fructus (Fruits of Evodia rutaecarpa var. bodinieri) and Its Components

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概要

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• The effects of 70% MeOH extract (EBC-ext) from Evodiae Fructus originating from the dried fruits of Evodia rutaecarpa var. bodinieri on allergic responses were investigated. In type I allergic models, EBC-ext at a dose of 500 mg/kg, p.o., inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats, and the histamine release from mast cells induced by antigen-antibody reaction. In a type IV allergic model, EBC-ext had an inhibitory effect on the effector phase in picryl chloride-induced contact dermatitis (PC-CD) in mice. Evodiamine, rutaecarpine and limonin isolated from the fruit also inhibited the PC-CD response. These results suggest that Evodiae Fructus possesses anti-allergic effects, and that the anti-allergic activities are partly attributable to the components mentioned above.

• 日本生薬学会の論文
• 1998-12-20

著者

• Iinuma M

  Gifu Pharmaceutical University

• Iinuma Munekazu

  岐阜薬科大学

• 角谷 真

  京都薬科大学

• Kubo M

  School Of Pharmaceutical Sciences Kinki University

• Kubo Michinori

  近畿大学 薬学部

• Kubo Michinori

  Kyoto Pharmaceutical University

• Kubo Michinori

  Faculty Of Pharmaceutical Sciences Kinki University

• Matsuda Hideaki

  Faculty Of Pharmaceutical Sciences Kinki University

• Tanaka Toshiyuki

  Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn

• Kubo M

  Kampo And Pharmacognosy Laboratory Tsumura And Co.

• Kubo M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Ido Yasuko

  Faculty Of Pharmaceutical Sciences Kinki University

• Tanaka Toshiyuki

  Gifu Pharmaceutical University

• Iinuma Munekazu

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• Tanaka Toshiyuki

  Department Of Applied Physics And Physico-informatics Keio University

• Yoshikawa Masato

  Faculty Of Science Himeji Institute Of Technology

• Kuwazima Hiroshi

  Faculty Of Pharmaceutical Sciences Kinki University

• Tanaka Toshiyuki

  Department Of Applied Chemistry Faculty Of Engineering University Of Toyama

• IINUMA Munekazu

  Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University

• YOSHIKAWA Masato

  Faculty of Pharmaceutical Sciences, Kinki University

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