Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line
スポンサーリンク
概要
- 論文の詳細を見る
Recently, we found that vaticanol C (a resveratrol tetramer), which was isolated from stem bark of Dipterocarpaceae, exhibited growth suppression and induction of apoptosis via the loss of mitochondrial membrane potential and consequent caspases activation. The detailed mechanisms are not clearly understood. We decided to attempt to gain further insight into the mechanisms underlying vaticanol C-induced apoptosis in HL-60 cells. Treatment of HL-60 cells with vaticanol C was found to cause a marked decrease in the level of phosphorylated extracellular signal-regulated kinase (ERK) concurrent with inhibited phosphorylation of its upstream kinase mitogen-activates protein kinase kinase (MEK). Moreover, exposure to vaticanol C led to a significant reduction in the level of phosphorylated Akt. Thus, vaticanol C induced inhibition of both ERK and Akt phosphorylation, resulting in reduced phosphorylation of Bad. These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways.
- 社団法人 日本農芸化学会の論文
- 2005-02-23
著者
-
IINUMA Munekazu
Gifu Pharmaceutical University
-
田中 利男
帝人株式会社 医薬岩国製造所
-
TANAKA Toshiyuki
Gifu Prefectural Institute of Health and Environmental Sciences
-
Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
-
Iinuma M
Gifu Pharmaceutical University
-
Iinuma Munekazu
岐阜薬科大学
-
Iinuma M
城西大学薬学部
-
Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
-
Tanaka T
Kvushu Univ. Fukuoka Jpn
-
Nozawa Yoshinori
Gifu International Institute of Biotechnology
-
Tanaka T
Osaka Univ. Osaka Jpn
-
Ohguchi Kenji
Gifu International Institute of Biotechnology
-
AKAO Yukihiro
Gifu International Institute of Biotechnology
-
Ito Tetsuro
Gifu Prefectural Institute of Health and Environmental Sciences
-
Ito Tetsuro
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
-
Ito T
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
-
Akao Y
Gifu International Institute Of Biotechnology
-
Nozawa Y
Gifu International Institute Of Biotechnology
-
MATSUMOTO Kenji
Gifu International Institute of Biotechnology
-
Tanaka Toshiyuki
Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn
-
Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
-
Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environmental Sciences
-
Araki Yoko
Nagaragawa Res. Center Api Co. Ltd.
-
Araki Yoko
Nagaragawa Research Center Api Co. Ltd.
-
Matsumoto K
Gifu International Institute Of Biotechnology
-
Matsumoto Keiji
Department Of Orthopaedic Surgery Shiga University Of Medical Science
-
Tanaka Toshiyuki
Gifu Pharmaceutical University
-
田中 徹明
Osaka Univ. Osaka Jpn
-
Ito Tetsuro
Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University
-
Ito T
Gifu Prefectrual Inst. Health And Environmental Sci. Kakamigahara Jpn
-
Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
-
Matsumoto K
Central Research Laboratory Hitachi Ltd.
-
Tanaka Terumichi
Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O
関連論文
- Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells(Biopharmacy)
- Hydroxychavicol : a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
- Histamine Release Inhibitory Activity of Piper nigrum Leaf(Pharmacognosy)
- Flavonol Glycosides in Leaves of Two Diospyros Species
- Antinociceptive Activities of 70% Methanol Extract of Evodiae Fructus(Fruit of Evodia rutaecarpa var.bodinerri) and Its Alkaloidal Components.
- Antinociceptive Activities of 70% methanol Extract of Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components
- Studies of Cuticle Drugs from Natural Sources. IV. Inhibitory Effects of Some Arctostaphylos Plants on Melanin Biosynthesis
- Identification of Lac Dye Components by Electrospray High Performance Liquid Chromatography-Tandem Mass Spectrometry
- P-448 STRUCTURES OF STILBENE OLIGOMERS IN DIPTEROCARPACEAEOUS PLANTS
- New resveratrol oligomers in the stem bark of Vatica pauciflora
- Six New Heterocyclic Stilbene Oligomers from Stem Bark of Shorea hemsleyana.
- Five New Oligostilbenes with One or Two Dihydrofurans form the Stem Bark of Vatica rassak.
- A Novel Bridged Stilbenoid Trimer and Four Highly Condensed Stilbenoid Oligomers in Vatica rassak.
- A New Resveratrol Octamaer, Vateriaphonol A, in Vateria indica.
- Quantitative Analysis of All Types of β-Carboline Alkaloids in Medicinal Plants and Dried Edible Plants by High Perofrmance Liquid Chromatography with Selective Fluorometric Detection.
- Beta-Carboline Alkaloids in Crude Drugs
- Effects of 70% Methanol Extract from Evodiae Fructus(Fruit of Evodia rutaecarpa var.bodinieri)and Its Alkaloidal Compnents on Blood Circulation
- Two Taxane Diterpenes from Taxus mairei
- A New Dihydrostilbene in Dendrobium chrysathum.
- Polysulfanes in the Volatile Oils of Ferula Species.
- イソカルバサイクリンメチルエステル含有 O/W エマルジョン製剤 TTC-909 の体内動態 (第4報) 単回静脈内投与後のイヌにおける血中濃度, 排泄および代謝
- イソカルバサイクリンメチルエステル含有 O/W エマルジョン製剤 TTC-909 の体内動態 (第2報) ラットにおける代謝
- A Potent Apoptosis-Inducing Activity of a Sesquiterpene Lactone, Arucanolide, in HL60 Cells : a Crucial Role of Apoptosis-Inducing Factor
- Stilbene Oligomers in Roots of Sophora davidii.
- Anti-Oral Microbiaal Activity of Isoflavonoids I Root Bark of Ormosia monosperma.
- Flavonol Glycosides in Epimedium Species
- Flavonol Glycosides from Epimedium sagittatum
- A Novel Coumaronochromone from the Stems of Euchresta japonica and its Antibacterial Activity
- Prenylisoflavones from Euchresta japonica
- Three Prenylflavones from Euchresta japonica
- 8,2'-Dihydroxyflavone from Primula pulverulenta
- 2', 5'-Dihydroxyflavone and its 5'-Acetate : Novel Compounds from the Farinose Exudate of Primula
- Two New Flavones in Citrus reticulata.
- Revised structure of Neoflavone in Coutarea hexandra.
- Synthesis of Flavonoids in Scutellaria spp. II. : Synthesis of 2', 6'-Dioxygenated Flavones.
- Flavonoids Syntheses. VI. : Synthesis and Spectral Properties of 4-Arylcoumarins (Neoflavones).
- Acylated Luteolin Glucosides from Salix gilgiana.
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
- Isoflavanones in Roots of Sophora secundiflora.
- Antibacterial Activity of Stilbene Oligomers against Vancomycin-Resistant Enterococci (VRE) and Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Synergism with Antibiotics
- A Monoterpene Glucoside and Three Megastigmane Glycosides from Juniperus communis var. depressa
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Stilbene Derivatives from Two Species of Gnetaceae
- Four New Glucosides of Stilbene Oligomers from theStem of Gnetum gnemonoides
- Stilbenoids in Lianas of Gnetum parvifolium
- Three New Trimeric Stilbenes from Gnetum gnemon
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Four New Glucosides of Stilbene Oligomers From the Stem of Gnetum gnemonoides.
- Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coli 0157 : H7.
- Stilbenoid in Lianas of Gnetum parvifolium.
- Stilbene Derivatives from Two Species of Gnetaceae
- Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coil O157 : H7
- Stilbenoids in Lianas of Gnetum parvifolium
- Testosterone 5α-Reductase Inhibitory Active Constituents of Piper nigrum Leaf(Pharmacognosy)
- Resveratrol Tetramers with a C_6-C_3 or a C_1 Unit from Upuna borneensis
- Resveratrol Oligomers and Their O-Glucosides from Cotylelobium lanceolatum
- A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
- Resveratrol Derivatives from Upuna borneensis
- Three New Trimeric Stilbenes from Gnetum gnemon.
- Six Flavonostilbenes from Gnetum africanum and Gnetum gnemon
- Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
- Antioxidant Activity of Hydroxyflavonoids
- Antiproliferative Effects Associated with Membrane Lipid Interaction of Green Tea Catechins
- Cell Growth Inhibition by Membrane-Active Components in Brownish Scale of Onion
- Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells(Molecular and Cell Biology)
- Stilbenoids with One Epoxy Group from Cotylelobium lanceolatum
- Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line
- Stilbenoids from Leaves of Upuna borneensis
- New Phenylpropanoid Glycosides from Juniperus communis var. depressa
- Antibacterial Activity of Extracts Prepared from Tropical and Subtropical Plants on Methicillin-Resistant Staphylococcus aureus
- Allergy-Preventive Effects of the Flowers of Impatiens textori
- Allergy-Preventive Flavonoids from Xanthorrhoea hastilis
- Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines
- Inhibitory Activity of Plant Stilbene Oligomers against DNA Topoisomerase II(Pharmacognosy)
- Nepalensinols D-G, New Resveratrol Oligomers from Kobresia nepalensis (Cyperaceae) as Potent Inhibitors of DNA Topoisomerase II
- Anti-Platelet and Membrane-Rigidifying Flavonoids in Brownish Scale of Onion
- Inhibitory Effects of Resveratrol Derivatives from Dipterocarpaceae Plants on Tyrosinase Activity(Biochemistry & Molecular Biology)
- Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum(Biochemistry & Molecular Biology)
- Vaticanol C, a Novel Resveratrol Tetramer, Inhibits Cell Growth through Induction of Apoptosis in Colon Cancer Cell Lines
- Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ.(Pharmacognosy)
- Effects on Blood Pressure Decrease in Response to PAF of Impatiens textori MIQ.(Pharmacognosy)
- First Synthesis of Subelliptenone F, an Inhibitor of Topoisomerase II
- Complex Flavonoids from Pityrogramma Frond Exudates : Synthesis of Two Flavones with C-C Linked Dihydrocinnamoyl Substituents.
- Spectral Characters of a Complex Flavonoid Isolated from the Farinose Exudate of Pityrogramma calomelanos.
- Flavonoids Syntheses. VI. : Synthesis and Spectral Properties of 4-Arylcoumarins (Neoflavones)(Pharmacognosy,Chemical)
- Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice
- 4-(2-Aminoethylamino)-7H-benz[de]benzimidazo[2,1-a]isoquinoline-7-one as a Highly Sensitive Fluorescent Labeling Reagent for Carnitine
- Hopeafuran and a C-Glucosyl Resveratrol Isolated from Stem Wood of Hepea utilis.
- Two xanthones from Root Bark of Calophyllum inophyllum.
- Hopeafuran and a C-Glucosyl Resveratrol Isolated from Stem Wood of Hopea utilis
- Four Dimeric Stilbenes in Stem Lianas of Gnetum africanum
- Dimeric Stilbenes from Stem Lianas of Gnetum africanum
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Antinociceptive and Antiinflammatory Activities of Evodiamine and Rutaecarpine
- Effects of 70% Methanol Extract from Evodiae Fructus (Fruit of Evodia rutaecarpa var. bodinieri) and Its Alkaloidal Components on Blood Circulation
- Anti-allergic Activities of 70% Methanol Extract of Evodiae Fructus (Fruits of Evodia rutaecarpa var. bodinieri) and Its Components
- Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis
- Isoflavonoids in Roots of Sophora fraseri.
- Identification of Phenolic Compounds in Aquilaria crassna Leaves Via Liquid Chromatography-Electrospray Ionization Mass Spectroscopy
- Characterization of a Glycyrrhizin-Deficient Strain of Glycyrrhiza uralensis