Anti-Platelet and Membrane-Rigidifying Flavonoids in Brownish Scale of Onion
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概要
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The bio-activity of the brownish scale of onion (Allium cepa) was studied together with identifying the active components and addressing the mode of action. A crude MeOH extract (0.5-1.0 mg/ml) showed the inhibitory effects on human platelet aggregation induced by collagen, adenosine 5′-diphosphate (ADP), thrombin and epinephrine. The anti-platelet extract (1.0μg/ml) rigidified liposomal membranes by acting on the hydrocarbon core more intensively than the surface of membrane lipid bilayers. Serial solvent extractions and chromatographic purifications provided four isolates which were structurally identified as different quercetin dimers (1 and 2), quercetin (3) and quercetin-4′-glucoside (4). The flavonoidal components 1, 3, 2 and 4 (0.5-2 mM) inhibited collagen-induced platelet aggregation in increasing order of intensity. More active 1 and 3 (2 mM) also dissociated the aggregates produced by ADP. The anti-platelet flavonoids (0.25-10 μM) acted on liposomes of the lipid composition resembling human platelets to cause membrane rigidification which was greatest in the order of 1, 2, 3 and 4. The interaction with membrane lipids to modify membrane fluidity appears to be partly responsible for the anti-aggregatory and disaggregatory effects on human platelets. Although the inedible scale of onion is usually regarded as waste, it has the possibility to be a medicinal resource.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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IINUMA Munekazu
Gifu Pharmaceutical University
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Hatano Tsutomu
Okayama Univ. Okayama Jpn
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FURUSAWA Miyuki
Gifu Prefectural Institute of Health and Environmental Sciences
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TANAKA Toshiyuki
Gifu Prefectural Institute of Health and Environmental Sciences
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Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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Iinuma M
城西大学薬学部
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Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
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Tanaka T
Osaka Univ. Osaka Jpn
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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白瀧 義明
Gifu Prefectural Institute Of Health And Environmental Sciences
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Tanaka Toshiyuki
Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn
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NAKAYA Ken-ichi
Gifu Prefectural Institute of Health and Environmental Sciences
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Nakaya Ken-ichi
Gifu Prefectural Institute Of Health And Environmental Science
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
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Tsuchiya Hironori
Asahi University School of Dentistry
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Nagayama Motohiko
Asahi University School of Dentistry
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Nagayama Motohiko
Department of Dental Basic Education, Asahi University School of Dentistry
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Furasawa M
Gifu Prefectural Institute Of Health And Environmental Sciences
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波多野 力
岡山大学・院医歯薬・創薬
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Nakaya K
Showa Pharmaceutical Univ. Tokyo Jpn
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Tanaka Toshiyuki
Gifu Pharmaceutical University
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Nagayama Motohiko
Department Of Dental Basic Education Asahi University School Of Dentistry
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Nagayama Motohiko
Asahi Univ. School Of Dentistry Gifu Jpn
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Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
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Tanaka Terumichi
Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O
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