Synergistic Effect of [10]-Gingerol and Aminoglycosides against Vancomycin-Resistant Enterococci (VRE)(Microbiology)
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概要
- 論文の詳細を見る
An extract from ginger (root of Zingiber officinale) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). The effective compound was isolated and identified as [10]-gingerol. In the presence of [10]-gingerol at 1/10 concentration of its own MIC, the MIC of arbekacin was lowered by 1/32 to 1/16. [10]-Gingerol also reduced the MICs of other aminoglycosides, and of bacitracin and polymixin B, but not of other antimicrobial agents tested. Because [10]-gingerol reduced the MICs of several aminoglycosides both in strains possessing or lacking aminoglycoside-modification enzymes, it seems that the effect of [10]-gingerol is not related to these enzymes, which mainly confer bacterial resistance against aminoglycosides. It seemed that a detergent-like effect of [10]-gingerol potentiated the antimicrobial activity of the aminoglycosides. In fact, some detergents such as sodium dodecyl sulfate (SDS) and Triton X-100 reduced the MICs of aminoglycosides, bacitracin and polymixin B in VRE. Since the intrinsic resistance to aminoglycosides in enterococci is due to low level of entry of the drugs into the cells, increase in the membrane permeability caused by [10]-gingerol will enhance the influx of aminoglycosides into enterococcal cells.
- 社団法人日本薬学会の論文
- 2006-03-01
著者
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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波多野 力
Department Of Pharmacognosy Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayam
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SHIOTA Sumiko
Laboratory of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
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KURODA Teruo
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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HATANO Tsutomu
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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TSUCHIYA Tomofusa
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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YOSHIDA Takashi
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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KARIYAMA Reiko
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical
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NAGOSHI Chihiro
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Hatano Tsutomu
岡山大学 医歯薬学総合研究科分子微生物学
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吉田 哲也
広島大学医学部
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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Kuroda T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Kuroda Teruo
岡山大学 分子微生物学
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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TSUTSUMI Tomoaki
National Institute of Health Sciences
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Tsuchiya Tomofusa
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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Yoshida Takashi
Department Of Agriculture Kyoto University
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Kayahara Takashi
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida T
College Of Pharmaceutical Sciences Matsuyama University
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takuji
Showa Pharmaceutical University
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Shimura S
Central Laboratory Lotte Co. Ltd.
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Shiota Sumiko
Laboratory Of Pathogenic Microbiology School Of Pharmacy Shujitsu University
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Kuroda T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Kariyama Reiko
Department Of Urology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Nagoshi Chihiro
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Kuroda Teruo
Department Of Microbiology Faculty Of Pharmaceutical Science Okayama University
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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Kariyama Reiko
Department Of Urology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sc
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Kuroda Teruo
Department of Genome Applied Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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