Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE)(Microbiology)
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概要
- 論文の詳細を見る
An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 μg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.
- 社団法人日本薬学会の論文
- 2007-06-01
著者
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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波多野 力
Department Of Pharmacognosy Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayam
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SHIOTA Sumiko
Laboratory of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
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KURODA Teruo
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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HATANO Tsutomu
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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TSUCHIYA Tomofusa
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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HORIUCHI Kumiko
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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YOSHIDA Takashi
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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吉田 隆志
岡山大学薬学部
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Hatano Tsutomu
岡山大学 医歯薬学総合研究科分子微生物学
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吉田 哲也
広島大学医学部
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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Kuroda T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Kuroda Teruo
岡山大学 分子微生物学
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Takahashi Y
Microbial Chemistry Research Center
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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TSUTSUMI Tomoaki
National Institute of Health Sciences
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Tsuchiya Tomofusa
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida T
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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Takahashi Y
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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Yoshida Takashi
Department Of Agriculture Kyoto University
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Yoshida T
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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Kayahara Takashi
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida T
College Of Pharmaceutical Sciences Matsuyama University
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takuji
Showa Pharmaceutical University
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Shimura S
Central Laboratory Lotte Co. Ltd.
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Shiota Sumiko
Laboratory Of Pathogenic Microbiology School Of Pharmacy Shujitsu University
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Kuroda T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Horiuchi Kumiko
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Kuroda Teruo
Department Of Microbiology Faculty Of Pharmaceutical Science Okayama University
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Kuroda Teruo
Department of Genome Applied Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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