Relationship between the Structures and the Antitumor Activities of Tannins(Pharmacological)

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概要

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• Sixty-three tannins and related polyphenols were intraperitoneally injected into mice at 4d before intraperitoneal sarcoma-180 cell inoculation, and their antitumor activities were evaluated. The condensed tannins and related compounds all showed negligible activity. As regards the hydrolyzable tannins, active compounds were found among ellagitannins. In particular, dimeric ellagitannins such as oenothein B, rugosin E, rugosin D, gemin A and coriariin A showed significantly higher antitumor activity than agrimoniin, which we previously reported as an antitumor tannin. Coriariin A, which has four galloyl groups instead of two hexahydroxydiphenoyl groups of agrimoniin, showed the strongest activity. It seems to be essential for marked antitumor activity that ellagitannins should possess a dimeric structure with several galloyl groups on the glucose core.

• 社団法人日本薬学会の論文
• 1987-02-25

著者

• 宮本 謙一

  北陸大学 薬学部

• 吉田 隆志

  Faculty of Pharmaceutical Sciences, Okayama University

• 奥田 拓男

  Faculty of Pharmaceutical Sciences, Okayama University

• 吉田 隆志

  Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University

• 宮本 謙一

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 岸 信治

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 越浦 良三

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 波多野 力

  Faculty of Pharmaceutical Sciences, Okayama University

• 宮本 謙一

  北陸大学薬学部

• 奥村 智子

  Faculty Of Pharmaceutical Sciences Okayama University

• 奥田 拓男

  Faculty Of Parmaceutical Sciences University

• 越浦 良三

  Research Laboratory for Development of Medicine, Hokuriku University, School of Pharmacy

• 吉田 隆志

  Faculty Of Pharmaceutical Sciences Kyoto University

• 越浦 良三

  Research Laboratory For Development Of Medicine Hokuriku University School Of Pharmacy

• 越浦 良三

  Department Of Chemistry Research Institute Of Tuberculosis Kanazawa University

• 岸 信治

  Department Of Pharmacology Hokuriku University School Of Pharmacy

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