硫酸アミノグアニジン及び関連化合物のニワトリ胚に及ぼす影響

概要

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Morphological studies on the effects of ten guanidine, three urea, two thiourea derivatives and others including anticancer agents on chick embryos were examined on the 14th day of incubation, when each drug was injected into the albumen of fertile eggs of the 5th day ofincubation. Aminoguanidine sulfate (AG) produced retardation of the growth of liver and hypoplasia of gallbladder of chick embryos, but did not cause any external abnormality. Hydroxyurea, semicarbazide, ethionine, mitomycin C (MMC) and vinblastine induced severe external anomalies. Hypoplasia of gallbladder and hepatic lesion were also observed after the injection of these drugs. Anomalies produced by MMC on the gallbladder and liver were similar to those by AG regardless of structural similality. On the other hand, guanidine derivatives produced neither AG-like abnormalities nor other marked anomalies. Consequently, the effect of AG on the liver and gallbladder of chick embryo was thought to be due to a peculiarity of its structure.
社団法人日本薬学会の論文
1985-09-25