Isolation of Agrimoniin, an Antitumor Constituent, from the Roots of Agrimonia pilosa LEDEB.

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概要

• 論文の詳細を見る

• The antitumor activities of various extracts from the roots of Agrimonia pilosa LEDEB. were studied. Each extract was given intraperitoneally to mice once at 4 d before the intraperitoneal inoculation of mouse mammary carcinoma MM2 cells, and the non-sugar fractions with median polarity showed antitumor activity. Agrimoniin was isolated from the antitumor active fractions. Agrimoniin itself showed antitumor activity when given as a pre- or posttreatment ; a single dose of 10 to 30 mg/kg of agrimoniin resulted in almost complete rejection of the tumor by the test mice. Agrimoniin also possessed a high degree of cytotoxicity but this activity was significantly reduced by the addition of serum to the culture medium.

• 社団法人日本薬学会の論文
• 1985-09-25

著者

• 田口 平八郎

  Tsumura Central Research Laboratories Tsumura & Co.

• 宮本 謙一

  北陸大学 薬学部

• 宮本 謙一

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 越浦 良三

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 池谷 幸信

  Department of Pharmacology, Hokuriku University School of Pharmacy

• 池谷 幸信

  武蔵野大学薬学部薬学研究所

• 田口 平八郎

  津村研究所

• 池谷 幸信

  津村研究所

• 宮本 謙一

  北陸大学薬学部

• 池谷 幸信

  (株)ツムラ中央研究所

• 池谷 幸信

  Research Institute For Biology & Chemistry Tsumura & Co.

• 池谷 幸信

  生物・化学研究所

• 池谷 幸信

  Tsumura Central Research Laboratories Tsumura & Co.

• Ikeya Y

  Tsumura Central Research Laboratories Tsumura & Co.

• 越浦 良三

  Research Laboratory for Development of Medicine, Hokuriku University, School of Pharmacy

• 越浦 良三

  Research Laboratory For Development Of Medicine Hokuriku University School Of Pharmacy

• 越浦 良三

  Department Of Chemistry Research Institute Of Tuberculosis Kanazawa University

• 田口 平八郎

  Tsumura Laboratory

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