Isolation of Agrimoniin, an Antitumor Constituent, from the Roots of Agrimonia pilosa LEDEB.

元データ 1985-09-25 社団法人日本薬学会

概要

The antitumor activities of various extracts from the roots of Agrimonia pilosa LEDEB. were studied. Each extract was given intraperitoneally to mice once at 4 d before the intraperitoneal inoculation of mouse mammary carcinoma MM2 cells, and the non-sugar fractions with median polarity showed antitumor activity. Agrimoniin was isolated from the antitumor active fractions. Agrimoniin itself showed antitumor activity when given as a pre- or posttreatment ; a single dose of 10 to 30 mg/kg of agrimoniin resulted in almost complete rejection of the tumor by the test mice. Agrimoniin also possessed a high degree of cytotoxicity but this activity was significantly reduced by the addition of serum to the culture medium.

著者

田口 平八郎 Tsumura Central Research Laboratories Tsumura & Co.
宮本 謙一 北陸大学 薬学部
宮本 謙一 Department of Pharmacology, Hokuriku University School of Pharmacy
越浦 良三 Department of Pharmacology, Hokuriku University School of Pharmacy
池谷 幸信 Department of Pharmacology, Hokuriku University School of Pharmacy
池谷 幸信 武蔵野大学薬学部薬学研究所
田口 平八郎 津村研究所
池谷 幸信 津村研究所
宮本 謙一 北陸大学薬学部
池谷 幸信 (株)ツムラ中央研究所
池谷 幸信 Research Institute For Biology & Chemistry Tsumura & Co.
池谷 幸信 生物・化学研究所
池谷 幸信 Tsumura Central Research Laboratories Tsumura & Co.
Ikeya Y Tsumura Central Research Laboratories Tsumura & Co.
越浦 良三 Research Laboratory for Development of Medicine, Hokuriku University, School of Pharmacy
越浦 良三 Research Laboratory For Development Of Medicine Hokuriku University School Of Pharmacy
越浦 良三 Department Of Chemistry Research Institute Of Tuberculosis Kanazawa University
田口 平八郎 Tsumura Laboratory

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