Structure Determination of Biliary Metabolites of Schizandrin in Rat and Dog

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概要

• 論文の詳細を見る

• After oral administration of schizandrin (1) to rat, the bile was collected and treated with β-glucuronidase and arylsulfatase. Eleven metabolites, SZ-M0 (3), SZ-M1 (4), SZ-M2 (5), SZ-M3 (6), SZ-M4 (7), SZ-M5 (8), SZ-M6 (9), SZ-M7 (10), SZ-M8 (11), SZ-M9 (12) and SZ-M10 (13) were isolated from the bile treated with the enzymes. The bile after oral administration of 1 to dog was collected and treated with enzymes in the same way, and eight metabolites, 3-8,10 and SZ-MD2 (14) were isolated from the bile treated with enzymes. The structures of these metabolites were determined on the basis of chemical and spectral studies. The major metabolite in the bile of rat was 7 and the major metabolites in the bile of dog were 7 and 14.

• 社団法人日本薬学会の論文
• 1995-01-15

著者

• 竹田 秀一

  株式会社 ツムラ ツムラ中央研究所

• 池谷 幸信

  武蔵野大学薬学部薬学研究所

• 丸野 政雄

  株式会社 ツムラ ツムラ中央研究所

• 尾山 力

  Tsumura Central Research Laboratories Tsumura & Co.

• 池谷 幸信

  津村研究所

• 丸野 政雄

  ツムラ中央研究所

• 菅間 恒

  Tsumura Central Research Laboratories Tsumura & Co.

• 池谷 幸信

  (株)ツムラ中央研究所

• 丸野 政雄

  Tsumura Central Research Laboratories, Tsumura & Co.,

• 池谷 幸信

  Tsumura Laboratory

• 池谷 幸信

  Research Institute For Biology & Chemistry Tsumura & Co.

• 池谷 幸信

  Tsumura Central Research Laboratories

• 池谷 幸信

  生物・化学研究所

• 金子 雅一

  株式会社ツムラ ツムラ中央研究所 安全性・代謝研究部

• 小野 裕正

  株式会社 ツムラ ツムラ中央研究所

• 若松 武

  株式会社ツムラ ツムラ中央研究所 安全性・代謝研究部

• 池谷 幸信

  Tsumura Central Research Laboratories Tsumura & Co.

• 田中 正英

  Tsumura Central Research Laboratories, Tsumura & Co.,

• 若松 武

  Tsumura Central Research Laboratories, Tsumura & Co.,

• 小野 裕正

  Tsumura Central Research Laboratories, Tsumura & Co.,

• 竹田 秀一

  Tsumura Central Research Laboratories, Tsumura & Co.,

• 田中 正英

  Tsumura Central Research Laboratories Tsumura & Co.

• 竹田 秀一

  Tsumura & Co. Tsumura Res. Laboratories

• 丸野 政雄

  Tsumura Central Research Laboratories Tsumura & Co.

• Ikeya Y

  Tsumura Central Research Laboratories Tsumura & Co.

• 丸野 政雄

  Tsumura Central Research Laboratories

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