Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia(Medicinal Chemistry)

スポンサーリンク

概要

• 論文の詳細を見る

• We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia WILLDENOW, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of P. tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound 1 has cognitive improving and cerebral protective effects.

• 2004-07-01

著者

• Yamaguchi Toshiaki

  Kissei Pharmaceutical Co. Ltd. Central Research Laboratories

• IKEYA Yukinobu

  Research Division, Tsumura & Co.

• TAKEDA Shigefumi

  Research Division, Tsumura & Co.

• TUNAKAWA Mitsuo

  Research Division, Tsumura & Co.

• KARAKIDA Humito

  Research Division, Tsumura & Co.

• TODA Kouin

  Research Division, Tsumura & Co.

• YAMAGUCHI Takuji

  Research Division, Tsumura & Co.

• ABURADA Masaki

  Research Division, Tsumura & Co.

• Yamaguchi Takuji

  ツムラ中央研究所

• Yamaguchi Takuji

  Central Research Laboratory Tsumura & Co.

• Ikeya Yukinobu

  ツムラ中央研究所

• Ikeya Yukinobu

  Central Research Laboratory Tsumura & Co.

• Ikeya Yukinobu

  Research Division Tsumura & Co.

• 油田 正樹

  Medicinal Evaluation Laboratory Tsumura Research Institute

• Aburada M

  Fac. Of Pharmacy Musashino Univ.

• Aburada M

  Tsumura Research Inst. Pharmacology Ibaraki Jpn

• Tunakawa Mitsuo

  Central Research Laboratory Tsumura & Co.

• Toda Kouin

  Research Division Tsumura & Co.

• 竹田 秀一

  Tsumura & Co. Tsumura Res. Laboratories

• 油田 正樹

  ツムラ研究本部 医薬評価研究所

• Karakida Humito

  Research Division Tsumura & Co.

• Yamaguchi T

  Tsumura Res. Laboratories Tsumura & Co.

• Takeda Shuichi

  Department Of Drug Metabolism & Disposition Tsumura Research Institute Tsumura & Co.

関連論文

• 炭酸ガス含有無機塩浴の効果 : 体温、体循環と食物吸収
• テアニン投与による高酸素負荷ラット網膜血管新生への影響
• Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents(Pharmacology)
• Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia(Medicinal Chemistry)
• APP-Tgマウスの学習障害と周辺症状に対する抑肝散の効果
• チアミン欠乏マウスの社会的行動性低下および攻撃性増加に対する抑肝散の改善効果
• 抑肝散のパラクロロアンフェタミン誘発攻撃行動に対する改善作用
• General Pharmacological Properties of Dai-kenchu-to Extract
• General Pharmacological Properties of Daio-kanzo-to
• General Pharmacological Properties of Juzen-taiho-to
• General Pharmacological Properties of Hochu-ekki-to
• General Pharmacological Properties of Shakuyaku-kanzo-to
• 演題3 大建中湯の消化管運動機能改善作用(第8回小児外科漢方研究会(第40回日本小児外科学会総会ランチョンセミナー))
• E-039(31) 柴苓湯の尿排泄調節作用
• General Pharmacological Properties of Choto-san extracts
• An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy(Pharmacology)
• Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats
• Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after Multiple Dose Administration of TJ-8117 (Unipito), a Japanese Traditional Medicine for Renal Failure
• Pharmacokinetics of (-)Epicatechin 3-O-Gallate, Glycyrrhetic Acid and Rhein in Healthy Male Volunteers after a Single Dose Administration of TJ-8117 (Unpito), a Japanese Traditional Medicine for Renal Failure
• Antinociceptive Effect of Shakuyakukanzoto, a Kampo Medicine, in Diabetic Mice
• Glycyrrhizin induced hypokaliemia in laboratory animal(Endocrine system, Proceedings of the 32nd Annual Meeting)
• The influence of the sennosides on absorption of glycyrrhetic acid in rats
• Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by N^G-Nitro-L-arginine
• Antianginal Effects of Lercanidipine on the Vasopressin or Methacholine Induced Anginal Model in Rats(Pharmacology)
• Diabetic Complications in a New Animal Model (TSOD mouse) of Spontaneous NIDDM with Obesity
• Effect of Sairei-to on signal transduction of the vasopressin V2 receptor in rat renal cortex
• Effects of 17β-Estradiol and the Japanese Herbal Medicine Keishi-bukuryo-gan on the Release and Synthesis of Calcitonin Gene-RelatedPeptide in Ovariectomized Rats
• Structure Activity Relationships of Quinoxalin-2-one Derivatives as Platelet-Derived Growth Factor-β Receptor (PDGFβ R) Inhibitors, Derived from Molecular Modeling
• Convenient synthetic method for 3-(3-substituted indol-2-yl)quinoxalin-2- ones as VEGF inhibitor
• Synthesis and Evaluation of Carbamate Prodrugs of a Phenolic Compound
• Potent Platelet-Derived Growth Factor-β Receptor (PDGF-βR) Inhibitors : Synthesis and Structure-Activity Relationships of 7-[3-(Cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one Derivatives
• Indoor Cultivation and Cultural Characteristics of Wolfiporia cocos Sclerotia Using Mushroom Culture Bottles(Pharmacognosy)
• Monosodium glutamateによって誘発された肥満マウスの2型糖尿病の特徴
• Identification of Medicinal Atractylodes Based on ITS Sequences of nrDNA(Pharmacognosy)
• Synthesis of a Capillarisin Sulfur-Analogue Possessing Aldose Reductase Inhibitory Activity by Selective Isopropylation
• Molecular Identification of Tiandong(天冬) Derived from Asparagus cochinchinensis(Lour.) Merrill by Two Typical Deletions in cpDNA
• Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine
• The Diuretic Effect of Sairei-to Is Mediated by Nitric Oxide Production in Pentobarbital-Anesthetized Rats
• Structure Determination of Biliary Metabolites of Schizandrin in Rat and Dog
• The Effects of Hange-shashin-to on the Content of Prostaglandin E_2 and Water Absorption in the Large Intestine of Rats
• Pharmacological Studies on Antidiarrheal Effects of Hange-Shashin-To
• メタボリックシンドロームに対する漢方薬の効果 : 防風通聖散(TJ-62)の効果
• メタボリックシンドロームに対する漢方薬の効果 : 大柴胡湯(TJ-8)の効果
• A New Mouse Model Of Spontaneous Diabetes Derived from ddY Strain
• P-09 メタボリックシンドローム予防に対する漢方薬の効果(生活習慣病,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
• A Study of Cardiovascular Function in Tsumura Suzuki Obese Diabetes, a New Model Mouse of Type 2 Diabetes
• Physicochemical quality evaluation of natural compounds isolated from crude drugs : Standard compounds for the official specification and testing method of "Processed Aconite Root" and "Powdered Processed Aconite Root" in the Japanese Pharmacopoeia
• Nuclectide Sequence Specificity in DNA Cleavage Caused by Dihydropyrazines, a New Type of DNA Strand-Cleaving Agent
• A Carbon-Centered Radical as a Reaction Species in the DNA Strand-Breakage by D-Glucosamine
• FORMATION OF TRICYCLIC HETEROCYCLES FROM THE CONDENSATION REACTION OF 1,2-DIAMINES WITH 1,2-DIKETONES
• Preparation of Optically Active Succinic Acid Derivatives. II. Efficient and Practical Synthesis of KAD-1229
• Preparation of Optically Active Succinic Acid Derivatives. I. Optical Resolution of 2-Benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)-propionic Acid
• Preventive Effects of Bofutsushosan on Obesity and Various Metabolic Disorders(Pharmacology)
• Efficacy of Tokishakuyakusan on the Anemia in the Iron-Deficient Pregnant Rats(Biopharmacy)
• Transformation of Schizandrin into Gomisin A by Use of Microbial O-Demethylation and Chemical Reactions
• PHARMACOLOGICAL STUDIES ON GINGER. III. EFFECT OF THE SPINAL DESTRUCTION ON (6)-SHOGAOL-INDUCED PRESSOR RESPONSE IN RATS
• PHARMACOLOGICAL STUDIES ON GINGER. II. PRESSOR ACTION OF (6)-SHOGAOL IN ANESTHETIZED RATS, OR HINDQUARTERS, TAIL AND MESENTERIC VASCULAR BEDS OF RATS
• PHARMACOLOGICAL STUDIES ON GINGER. I. PHARMACOLOGICAL ACTIONS OF PUNGENT CONSTITUENTS, (6)-GINGEROL AND (6)-SHOGAOL
• Oxidative Stress Induced by a Dihydropyrazine Derivative(Molecular and Cell Biology)
• TJN-419 Improves Dextran Sulfate Sodium-Induced Colitis via Inhibition of Interleukin-12 Release
• TJN-259 Improves Mesangial Lesions in Experimental Immunoglobulin A Nephropathy in ddY Mice
• Inhibitory effects of compounds from Anemarrhenae Rhizoma on α-glucosidase and aldose reductase and its contents by drying conditions
• A New Acetylenic Compound from the Rhizomes of Atractylodes chinensis and Its Absolute Configuration
• Pharmacokinetics of Rhein from Onpi-to, an Oriental Herbal Medicine, in Rats
• Pharmacokinetics of (-)-Epicatechin-3-0-gallate, an Active Component of Onpi-to, in Rats
• Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
• Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(α,α-diphenyl-2-pyrrolidinemethanol) Carbonate
• The Practical Synthesis of a Uterine Relaxant, Bis(2-{[(2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl}amino)-1, 2, 3, 4-tetrahydronaphthalen-7-yl]oxy}-N, N-dimethylacetamide)Sulfate(KUR-1246)
• The Practical Synthesis of(2S)-7-Methoxy-1, 2, 3, 4-tetrahydro-2-naphthylamine via Optical Resolution of 2-(3-Methoxybenzyl)succinic Acid
• Asymmetric Borane Reduction of Prochiral Ketones Using Aluminum Triethoxide and Chiral Amino Alcohls
• The Herbal Medicine Tokishakuyakusan Increases Fetal Blood Glucose Concentrations and Growth Hormone Levels and Improves Intrauterine Growth Retardation Induced by N^ω-Nitro-L-arginine Methyl Ester
• Synthesis, Conformation, and Chemical Properties of New Mini Parallel Double-Stranded Peptides Conjugated with -Phe-Phe- and -Phe-Phe-X- Sequences
• Dihydropyrazine-Induced Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase
• SUBACUTE AND CHRONIC TOXICITY STUDIES OF TRIETHYLENETETRAMINE DIHYDROCHLORIDE (TJA-250) BY ORAL ADMINISTRATION TO F-344 RATS
• The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo(Biochemistry/Molecular Biology)
• Mutation Spectrum Induced by Dihydropyrazines in Escherichia coli(Molecular and Cell Biology)
• The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper (II)(Molecular and Cell Biology)
• The Effect of Herbal Medicine Toki-shakuyaku-san on Blood Pressure in an N^ω-Nitro-L-Arginine Methyl Ester-Induced Pre-eclampsia Rat Model During Pregnancy and the Postpartum Period
• Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition
• CHLOROPHYLL CATABOLISM AND ITS PHYSIOLOGICAL SIGNIFICANCE IN HIGHER PLANTS
• THE PRIMARY STEP IN CHLOROPHYLL CATABOLISM IN HIGHER PLANTS
• High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine
• Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities
• Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)
• Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection
• Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata
• Isolation of 8'-Phosphate Ester Derivatives of Amicoumacins : Structure-activity Relationship of Hydroxy Amino Acid Moiety
• AUTOMATIC MONITORING SYSTEM FOR THE MEASUREMENT OF BODY WEIGHT, FOOD AND WATER CONSUMPTION AND SPONTANEOUS ACTIVITY OF A MOUSE
• Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats
• Discrimination of Maidong (麦冬) Derived from Ophiopogon and Liriope Species by rbcL Sequences, and Their Chemical Components and Tuber Anatomy
• Molecular Identification of Tiandong(天冬) Derived from Asparagus cochinchinensis(Lour.) Merrill by Two Typical Deletions in cpDNA
• (E)-N-[(3,4-dimethoxyphenethyl)]-N-methyl-3-(3-pyridyl)-2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice
• Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
• Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells
• Polymethoxyflavonoids from Kaempferia parviflora Induce Adipogenesis on 3T3-L1 Preadipocytes by Regulating Transcription Factors at an Early Stage of Differentiation
• Tetrandrine Prevents Bone Loss in Sciatic-Neurectomized Mice and Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation
• 入浴習慣と身体・心理状況との関連
• Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice
• PS-052-2 肺葉切除例におけるCTスパイロメトリーを用いた術前後の局所肺機能の定量的評価(PS-052 肺機能 その他,第112回日本外科学会定期学術集会)
• Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.

もっと見る 閉じる

スポンサーリンク