Transformation of Schizandrin into Gomisin A by Use of Microbial O-Demethylation and Chemical Reactions
スポンサーリンク
概要
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The transformation of schizandrin (I) into gomisin A (II) was accomplished by use of a combination of biotransformation and chemical reactions. The biotransformation, microbial O-demethylation of I by Cunninghamella echinulata var. elegans (ATCC 9245) produced two novel metabolites [3-norschizandrin (IV) and 2-norschizandrin (VI)] and two known metabolites [gomisin T (III) and 13-norschizandrin (V)]. Among those metabolites, compound III was derived to II by the O-demethylation with a Lewis acid in the presence of an acid scavenger, followed by methylenation.
- 社団法人日本農芸化学会の論文
- 1994-06-23
著者
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Sakakibara Chiaki
Central Research Laboratories Tsumura & Co.
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Ikeya Yukinobu
Central Research Laboratory Tsumura & Co.
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Ikeya Yukinobu
Central Research Laboratories Tsumura & Co.
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Niitsu Kazuaki
Central Research Laboratories Tsumura & Co.
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Niitsu Kazuaki
Pharmacognosy & Medicinal Resources Research Department
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Tanaka Miyuki
Department Of Home Economics Aichi University Of Education
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Kanatani Hirotoshi
Central Research Laboratories, Tsumura & Co.
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Tanaka Masahide
Central Research Laboratories, Tsumura & Co.
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Wakamatsu Takeshi
Central Research Laboratories, Tsumura & Co.
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Maruno Masao
Central Research Laboratories, Tsumura & Co.
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Maruno Masao
Central Research Laboratories Tsumura & Co.
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Kanatani Hirotoshi
Central Research Laboratories Tsumura & Co.
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Wakamatsu Takeshi
Central Research Laboratories Tsumura & Co.
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