Efficacy of Tokishakuyakusan on the Anemia in the Iron-Deficient Pregnant Rats(Biopharmacy)

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概要

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• Iron-deficiency anemia not only causes insufficient oxygen delivery to the body of the mother, but creates serious conditions in the fetus, such as insufficient oxygen delivery and poor development, and its treatment has become an important issue. To elucidate the mechanism of the anemia-ameliorating action of Tokishakuyakusan, we investigated the effect of administration of Tokishakuyakusan on anemia-related parameters and the serum transferrin and erythropoietin levels, erythrocyte morphology, and bone marrow cells in pregnant rats and in pregnant rats with iron-deficiency anemia. The results showed that Tokishakuyakusan significantly improved the low erythrocyte count, hemoglobin, and hematocrit values of the pregnant rats in the iron-deficient state, increased the proportion of normal erythrocytes in terms of erythrocyte morphology, increased the proportion of erythroblasts among bone marrow cells, and also significantly increased the erythropoietin and transferrin levels in the blood. These findings suggested that Tokishakuyakusan promotes erythrocyte differentiation in iron-deficiency anemia, and that it possesses anemia-ameliorating efficacy.

• 公益社団法人日本薬学会の論文
• 2007-08-01

著者

• Tashiro Shin-ichi

  Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn

• TASHIRO Shin-ichi

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• Shimada Tsutomu

  Research Institute Of Pharmaceutical Sciences Musashino University

• ABURADA Masaki

  Research Division, Tsumura & Co.

• 油田 正樹

  Res. Inst. Of Pharmaceutical Sciences Musashino Univ.

• 油田 正樹

  Medicinal Evaluation Laboratory Tsumura Research Institute

• 赤瀬 朋秀

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Aburada M

  Fac. Of Pharmacy Musashino Univ.

• Aburada M

  Tsumura Research Inst. Pharmacology Ibaraki Jpn

• AKASE Tomoko

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• AKASE Tomohide

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• Tashiro Shin-ichi

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Akase Tomoh

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Akase Tomoko

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• Tashiro Shin-ichi

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• 油田 正樹

  ツムラ研究本部 医薬評価研究所

• HIHARA Emiko

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• KOJIMA Kazuko

  Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University

• Tashiro S

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Shimada Tsutomu

  Res. Inst. Of Pharmaceutical Sciences Musashino Univ.

• Hihara Emiko

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Kojima Kazuko

  Research Institute Of Pharmaceutical Sciences Faculty Of Pharmacy Musashino University

• Akase Tomohide

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Aburada Masaki

  Musashino Univ. Tokyo Jpn

• Aburada Masaki

  Research Institute Of Pharmaceutical Sciences Musashino University

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