Silymarin Prevents UV Irradiation-Induced A375-S2 Cell Apoptosis(Pharmacology)

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概要

• 論文の詳細を見る

• Silymarin, a plant flavonoid from milk thistle (Silybum marianum [L.] GAERTNER) was first evaluated for its protective effect against UV irradiation-induced apoptosis in human malignant melanoma cells (A375-S2 cells). Treatment with silymarin 500 μM for 12 h significantly inhibited UV irradiation (2.4 J/cm^2, 5 min)-induced apoptosis in A375-S2 cells. Activities of caspase-9 and caspase-3 in UV-irradiated A375-S2 cells were effectively reduced by silymarin in a dose-dependent manner, while the expression of the inhibitor of caspase-activated DNase (ICAD), protein expression of Bcl-x_L (Bcl-2 family member), and the activity of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) were increased simultaneously. It is suggested that the inhibitory effect of silymarin is exerted by blockage of the caspase/ICAD pathway after increased expression of Bcl-x_L protein and activation of the ERK/MAPK pathway.

• 公益社団法人日本薬学会の論文
• 2004-07-01

著者

• Tashiro Shin-ichi

  Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn

• TASHIRO Shin-ichi

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• ONODERA Satoshi

  Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University

• IKEJIMA Takashi

  China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive

• Wu Li-jun

  Department Of Phytochemistry Shenyang Pharmaceutical University

• Wu Zhen

  中華人民共和国

• Wu Zhen

  Department Of Phytochemistry Shenyang Pharmaceutical University

• Wu L

  Department Of Phytochemistry Shenyang Pharmaceutical University

• Onodera S

  Dep. Of Clinical And Biomedical Sciences Showa Pharmaceutical Univ. Jpn

• Ikejima Takashi

  China-japan Res. Inst. Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univ. Chn

• LI Lin-Hao

  China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical Unive

• UCHIUMI Fumiaki

  Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Tashiro Shin-ichi

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Onodera Satoshi

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• Tashiro Shin-ichi

  Department Of Cinical And Biomedical Sciences Showa Pharmaceutical University

• Li Lin-hao

  China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer

• Uchiumi Fumiaki

  Department Of Gene Regulation Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Uchiumi Fumiaki

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Tashiro S

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• Onodera S

  Department Of Clinical And Biomedical Sciences Showa Pharmaceutical University

• ZHOU Bei

  Department of Phytochemistry, Shenyang Pharmaceutical University

• Zhou Bei

  China-japan Research Institute Of Medical And Pharmaceutical Sciences Shenyang Pharmaceutical Univer

• WU Zhen

  Department of Anesthesiology, Jiangyin Hospital Affiliated to Medical College of South-East University

• Ikejima Takashi

  China–Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University

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