The Involvement of ATP Produced via (ADP-Ribose)_n in the Maintenance of DNA Replication Apparatus during DNA Repair(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
The formation of ATP produced from poly(ADP-ribose) [(ADP-R)_n] has been suggested to be required to repair damaged DNA. Here we investigate whether this ATP is involved in DNA replication processes during DNA repair. Poly(ADP-ribosyl)ated mid-S phase cell nuclei, which were isolated from synchronized HeLa S3 cells followed by the treatment with a DNA damaging agent, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), were revealed to retain DNA replication synthesizing activity during preincubation for de-poly(ADP-ribosyl)ation only in the presence of pyrophosphate (PPi) before DNA synthesis was started by adding 3 mM ATP. This DNA replication activity was not maintained in the presence of a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG), Oenothein B (Oen B) during the preincubation with PPi. In the preincubation with PPi, μM orders of ATP was produced from (ADP-R)_n. These results point to an important function of ATP generated from (ADP-R)_n in nuclei for the maintenance of replication apparatus during DNA repair.
- 社団法人日本薬学会の論文
- 2007-03-01
著者
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Tanuma Sei-ichi
Department of Biochemistry, Tokyo University of Science
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HATANO Tsutomu
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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UCHIUMI Fumiaki
Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Takasawa Ryoko
Genome And Drug Research Center Tokyo University Of Science
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Hatano Tsutomu
Department Of Pharnlacognosy Faculty Of Pharmaceutical Sciences Okayama University
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MARUTA Hideharu
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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OKITA Naoyuki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Tanuma Sei-ichi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science:genome And
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Uchiumi Fumiaki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Maruta Hideharu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Okita Naoyuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Tanuma Sei-ichi
Department Of Biochemistry Faculty Of Pharmaceutical Science Science University Of Tokyo
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