<SYMPOSIUM : Biology of Aging and Age-associated Skin Disorders>BIOLOGICAL IMPLICATIONS OF APOPTOSIS/APOBIOSIS IN SENESCENCE AND LIFE-SPAN

概要

論文の詳細を見る
There are at least two major form of active or physiological cell death. The most well-know form is apoptosis, which is most commonly seen in renewing cells. It involves nucleosomal DNA fragmentation, chromatin condensation, nuclear collapse, and cell fragmentation. Tissue kinetic homeostasis in normal renewing tissues is maintained by a tightly regulated balance between cell proliferation/differentiation and apoptosis. Apoptosis is a mechanism for eliminating unwanted renewing cells from the cell community of multicellular organisms and involved in cell senescence. Abnormalities in the process of apoptosis cause serious diseases, such as cancer and AIDS. So, the major research attention has been focused on both understanding the etiology of apoptosis-diseases and developing therapeutic strategies. On the other hand, the minority of nondiving stable cells, such as neurons and cardiac muscle cells, is known to undergo cell death every days. Unlike apoptosis, in these naturally occurring cell death, the bulk of nuclei is condensed with large DNA frangmentation before cell shrinkage is manifest. The requirement for energy and large DNA fragmentation are more characteristic of this form of cell death. It is considered to relate to cell life-time and involve in the life-span of an organism. Thus, this form of cell death in nondividing stable cells has been termed apobiosis.
名古屋市立大学の論文
2000-01-31